Citation: Yong Hai Liu, Da Li Li, Lu De Lu, Zhen Yuan Miao. Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol[J]. Chinese Chemical Letters, ;2008, 19(7): 814-816. doi: 10.1016/j.cclet.2008.05.009 shu

Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol

a School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;
b School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 20 March 2008

A convenient approach for the preparation of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1 is developed.The target compound via four steps is synthesized from 4-bromo-2-(bromomethyl)-1-chlorobenzene and the isomers of undesired ortho-products were avoided during the preparation.
- Type 2 diabetes,
- Sodium glucose co-transporter 2,
- Inhibitor,
- Preparation
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