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Citation:
Na Zhang, Mei Li Guo, Ge Zhang, Run Ping Li. A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus[J]. Chinese Chemical Letters,
;2008, 19(7): 841-844.
doi:
10.1016/j.cclet.2008.04.036
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A new bakkenolide-type compound, bakkenolide-Va(1), was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR (1H, 13C, 1H-1H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-glucose deprivation and various types of oxidative insults.
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Keywords:
- Petasites tricholobus,
- Compositae,
- Bakkenolide-Va,
- Neuroprotection
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[1]
Chenchen Xie , Jun Liao , Yi Li , Yunan Zhang , Zhicheng Xiao , Yun Wang , Ting Chen , Liyan Xiong , Tao Pang , Xiangao Jiang , Feng Zhang , Chuan Zhang , Tingfang Wang . Synergistic anti-inflammatory effect of cascade nanozymes for neural recovery in ischemic stroke. Chinese Chemical Letters, 2026, 37(1): 110956-. doi: 10.1016/j.cclet.2025.110956
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[1]
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