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Yan Ling Li, Hao Fang, Wen Fang Xu, Bing He Wang. New synthetic way to prepare 2-aryl-8-(piperidin-4-yl)-5, 7-dimethoxy-4H-chromen-4-one as key intermediate for CDK inhibitor[J]. Chinese Chemical Letters,
;2008, 19(5): 541-543.
doi:
10.1016/j.cclet.2008.03.025
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As an important intermediate to study cyclin-dependent kinase (CDK) inhibitors, 2-aryl-8-(piperidin-4-yl)-5,7-dimethoxy-4H-chromen-4-one derivatives were prepared using β-diketone route with low yield. In our study, chalcone route has been investigatedand the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketoneroute. This new method will be an efficient way to start further research on new anticancer flavonoids.
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Keywords:
- Chalcone route,
- Closure,
- Flavopiridol
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