Citation: Yong Fu Huang, Li Qiao, A.Li Lv, Yue Hu Pei, Li Tian. Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2[J]. Chinese Chemical Letters, ;2008, 19(5): 562-564. doi: 10.1016/j.cclet.2008.03.018 shu

Eremophilane sesquiterenes from the marine fungus Penicillium sp. BL27-2

Yong Fu Huang ^a,b, ,
Li Qiao ^b ,
A.Li Lv ^b ,
Yue Hu Pei ^b ,
Li Tian ^c

a Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100094, China;
b School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
c College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao 266061, China

Received Date: 12 December 2007

Fund Project: This work was supported by 863 Hi-Tech Research and Development Program of China (Grant No. 2001AA624020) and the Fund for the 973-project from Ministry of Science and TechnologyChina (No. G1998051100).

Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidatedas 3-acetyl-9, 7 (11)-dien-7ot-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydro-xypetasol (4), 8α-hydroxy-13-deo-xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a newcompound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388,A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide tings in eremophilanemolecules were essential for their activity, and acetylation could enhance their activity.
- Marine fungus,
- Eremophilane sesquiterpenes,
- NMR analysis,
- Cytotoxic activity
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