Citation: Xin Ying Zhang, Xiao Yan Li, Xue Sen Fan, Xia Wang, Jian Ji Wang, Gui Rong Qu. A novel synthesis of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction in ionic liquid[J]. Chinese Chemical Letters, ;2008, 19(2): 153-156. doi: 10.1016/j.cclet.2007.12.009 shu

A novel synthesis of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction in ionic liquid

School of Chemical and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, PR China

Received Date: 18 September 2007

Fund Project: We are grateful to the National Natural Science Foundation of China (No. 20573034).

An efficient and novel procedure for the preparation of pyrazolo[3, 4-b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or eyanoaeetate in[bmim][BF₄] is described in this paper.Advantages of the method presented here include mild conditions, high yields together with a green nature and ease of recovery and reuse of the reaction medium.
- Pyrazolo[3,4-b]pyridine,
- Multi-component reaction,
- Ionic liquid
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