Citation: Tao Wang, Yi Hua Zhang, Hui Ji, Yan Ping Chen, Si Xun Peng. Synthesis and bioactivity of novel phthalimide derivatives[J]. Chinese Chemical Letters, ;2008, 19(1): 26-28. doi: 10.1016/j.cclet.2007.10.049 shu

Synthesis and bioactivity of novel phthalimide derivatives

a Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China;
b Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China

Received Date: 27 August 2007

Novel phthalimide derivatives (4a, 4b and 6a-6e) were designed as hybrids of thalidomide and NO-ASA, and their chemical synthesis and in vitro biological activities were presented. The preliminary results showed that compared to thalidomide 4a and 4b exhibited enhanced activities against ECV304 and HepG2 cells, whereas 6c was more potent against HepG2 cells.
- Thalidomide,
- NO-ASA,
- Antiangiogenic activity,
- Antitumor activity
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