Citation: Fang Yuan, Fu Chen, Qing Yu Xiang, Xuan Qin, Zhi Rong Zhang, Yuan Huang. Synthesis and characterization of HPMA copolymer-5-FU conjugates[J]. Chinese Chemical Letters, ;2008, 19(2): 137-140. doi: 10.1016/j.cclet.2007.10.035 shu

Synthesis and characterization of HPMA copolymer-5-FU conjugates

Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 29 June 2007

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30500636) and Ministry of Education (NCET-06-0786).

N-(2-Hydroxypropyl) methacrylamide copolymer-5-fluorouracil (PHPMA-FU) conjugates were synthesized by a novel and simplified synthetic mute, and characterized by UV, FTIR and HPLC analyses.The conjugated content of 5-fluorouracil (5-FU) was 3.41±0.07 wt%.The stabilities of PHPMA-FU conjugates under different conditions were studied.The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.
- HPMA copolymer,
- 5-Fluorouracil,
- Conjugates,
- Characterization,
- Stability
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