Citation: Rong Dong Li, Xin Zhai, Yan Fang Zhao, Ping Gong. Design,synthesis and antiproliferative activities of novel 5H-pyridazino[4,5-b]indoles[J]. Chinese Chemical Letters, ;2007, 18(10): 1191-1194. doi: 10.1016/j.cclet.2007.07.027 shu

Design,synthesis and antiproliferative activities of novel 5H-pyridazino[4,5-b]indoles

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China

Received Date: 16 April 2007

A novel series of 5H-pyridazino[4, 5-b]indoles were designed and synthesized in order to find novel potent anticancer compounds. The structures were confirmed by ¹H NMR and MS. Their antiproliferative activities against two cancer cell lines were tested by the MTT method in vitro. Three of compounds (1e, 1g, and 1h) exhibited potent antiproliferative activities, especially compound 1h (with IC₅₀ values of 5.2 μmol/L and 1.9 μmol/L against Bel-7402 and HT-1080, respectively). The preliminary structure-activity relationships of 5H-pyridazino[4, 5-b]indole derivatives were discussed.
- 5H-Pyridazino[4,5-b]indole derivatives,
- Synthesis,
- Antipro liferative activities
1. [1]
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2. [2]
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3. [3]
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4. [4]
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5. [5]
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14. [14]
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15. [15]
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19. [19]
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