Citation: Jin Pei Zhou, Dan Li, Xiao Ming Wu, Wen Cai Ye, Lu Yong Zhang. Synthesis and antitumor activity of derivatives of 23-hydroxybetulinic acid[J]. Chinese Chemical Letters, ;2007, 18(10): 1195-1198. doi: 10.1016/j.cclet.2007.07.017 shu

Synthesis and antitumor activity of derivatives of 23-hydroxybetulinic acid

a Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;
b Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China;
c National Drug Screening Center, China Pharmaceutical University, Nanjing 210038, China

Received Date: 13 April 2007

Fund Project: This research was supported by the National Natural Science Foundation of the People's Republic of China (No.30472083).

A series of natural product 23-hydroxybetulinic acid derivatives were prepared. In the preparation of mono-O-benzoyl ester derivative, it was observed that benzoyl group migrated from 3-O-to 23-O-position during the detritylation.
- 23-Hydroxybetulinic acid,
- Triterpenoid,
- Antitumor,
- Synthesis
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