Citation: Kun Zou, Jun Zhi Wang, Jun Wu, Yuan Zhou, Chuang Liu, Fei Jun Dan, Ya Xiong Zhang, Jin Yang. Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes[J]. Chinese Chemical Letters, ;2007, 18(10): 1239-1242. doi: 10.1016/j.cclet.2007.06.018 shu

Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes

Kun Zou ^a, ,
Jun Zhi Wang ^a ,
Jun Wu ^b ,
Yuan Zhou ^a ,
Chuang Liu ^a ,
Fei Jun Dan ^a ,
Ya Xiong Zhang ^a ,
Jin Yang ^a

a Hubei Province Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University, Yichang 443002, China;
b Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology

Received Date: 12 March 2007

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No.30670213) and Key Scientific Program of China Three Gorges University (No.2005ZD007).The plant material was identified by Prof.Fa Ju Chen,China Three Gorges University,Hubei.

Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determined as (25S)-26-O-(β-D-glucopyranosyl)-furost-1β, 3β, 22α, 26-tetrol-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1) and (25R)-26-O-(β-D-glucopyranosyl)-furost-lβ, 3β 22α, 26-tetrol 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (2), on basis of chemical and spectroscopic evidences. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20 μg/mL.
- Tupistra chinensis Bak.,
- Furostanol saponin,
- COX-2,
- Folk medicines
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