Citation: Lin Wei Li, Dong Dong Wang, De Zhi Sun, Min Liu, You Ying Di, Hua Chao Yan. Thermodynamic study on the interaction between anti-tumor drug tegafur and human serum albumin[J]. Chinese Chemical Letters, ;2007, 18(7): 891-894. doi: 10.1016/j.cclet.2007.05.009 shu

Thermodynamic study on the interaction between anti-tumor drug tegafur and human serum albumin

College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China

Received Date: 11 December 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20543004), the Natural Science Foundation of Shandong Province (No. 2004zx15) and the Science Foundation of Liaocheng University (No. 31801).

The changes of thermodynamic properties of the system on interaction between tegafur and human serum albumin (HSA) and the changes of secondary structure units of HSA in the system at 298.15 K have been investigated by the Nano-Watt-Scale isothermal titration calorimetry (ITC), the Langmuirs binding model and the circular dichroism (CD) spectrometry.
- Tegafur,
- Human serum albumin,
- Isothermal titration calorimetry,
- Circular dichroism
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