Citation: Feng Zhi Liu, Hao Fang, Wen Fang Xu. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid[J]. Chinese Chemical Letters, ;2007, 18(4): 393-396. doi: 10.1016/j.cclet.2007.01.048 shu

An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid

School of Pharmacy, Shandong University, Jinan 250012, China

Fund Project: We are grateful to the National Natural Science Foundation of China (No. 20272033) for financial support for this work.

An efficient way to coupling amine with the derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid was reported in this paper.We have found that the synthesis of derivatives is problematic with the commonly used DCC/HOBT method. As a substitute, the mixed anhydride method was adopted. A series of 6-(3-nitroguanidino)hexanamidopyrrolidine derivatives were prepared with this method.
- Synthesis,
- 6-(3-Nitroguanidino)hexanamidopyrrolidine derivatives,
- The mixed anhydride method
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