Citation: Xue Fei Yan, Ling Yi Kong. Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives[J]. Chinese Chemical Letters, ;2007, 18(4): 380-382. doi: 10.1016/j.cclet.2007.01.018 shu

Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 31 August 2006

Fund Project: The authors are grateful to Xiaoming Jia of the National Laboratory for Drug Screening and Jiangsu Center for Drug Screening,for cytotoxicity screening and Prof. Daqi Wang of Liaocheng University,for X-ray measurement.

A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3-methoxy-4-hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by ¹H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.
- 2-Aryl-5-alkyl-7-methoxylbenzo[b]furan,
- Neolignans,
- Synthesis,
- Cytotoxicity
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