Citation: Na Li, Junbiao Chang, Lingheng Kong, Shuangjing Wang, Dandan Wang, Miao Cheng, Xingwei Li. Co(III)/Zn(II)-catalyzed dearomatization of indoles and coupling with carbenes from ene-yne ketones via intramolecular cyclopropanation[J]. Chinese Journal of Catalysis, ;2018, 39(12): 1881-1889. doi: 10.1016/S1872-2067(18)63154-7 shu

Co(III)/Zn(II)-catalyzed dearomatization of indoles and coupling with carbenes from ene-yne ketones via intramolecular cyclopropanation

a Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, China;
b School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China;
c Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China

Received Date: 21 June 2018
Revised Date: 26 July 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (21525208, 21472186) and the research fund from Henan Normal University (5101034011009).

A straightforward and efficient protocol for dearomatizing indoles is described. The reaction, catalyzed by an inexpensive Co(Ⅲ)/Zn(Ⅱ) catalyst, starts from easily accessible N-pyrimidinyl indoles and ene-yne ketones. Mild reaction conditions, high diastereoselectivity, a broad substrate scope, effective functional group tolerance, and reasonable to remarkable yields were observed.
- Co(III)/Zn(II) catalysis,
- Dearomatization,
- Cyclopropanation,
- Carbene,
- Indole
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