Citation: Hui Chen, Min-Hui Li. Recent Progress in Fluorescent Vesicles with Aggregation-induced Emission[J]. Chinese Journal of Polymer Science, ;2019, 37(4): 352-371. doi: 10.1007/s10118-019-2204-5 shu

Recent Progress in Fluorescent Vesicles with Aggregation-induced Emission

Hui Chen ¹ ,
Min-Hui Li ^1,2,,

a.
Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, 75005 Paris, France
b.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China

Corresponding author: Min-Hui Li, min-hui.li@chimieparistech.psl.eu
Received Date: 1 November 2018
Revised Date: 28 November 2018
Accepted Date: 3 December 2018
Available Online: 21 January 2019

Fluorescent vesicles have recently attracted increasing attention because of their potential applications in bioimaging, diagnostics, and theranostics, for example, in vivo study of the delivery and the distribution of active substances. However, fluorescent vesicles containing conventional organic dyes often suffer from the problem of aggregation-caused quenching (ACQ) of fluorescence. Fluorescent vesicles working with aggregation-induced emission (AIE) offer an extraordinary tool to tackle the ACQ issue, showing advantages such as high emission efficiency, superior photophysical stability, low background interference, and high sensitivity. AIE fluorescent vesicles represent a new type of fluorescent and functional nanomaterials. In this review, we summarize the recent advances in the development of AIE fluorescent vesicles. The review is organized according to the chemical structures and architectures of the amphiphilic molecules that constitute the AIE vesicles, i.e., small-molecule amphiphiles, amphiphilic polymers, and amphiphilic supramolecules and supramacromolecules. The studies on the applications of these AIE vesicles as stimuli-responsive vesicles, fluorescence-guided drug release carriers, cell imaging tools, and fluorescent materials based on fluorescence resonance energy transfer (FRET) are also discussed.
- Vesicles,
- Polymersomes,
- Aggregation-induced emission,
- Small-molecule amphiphiles,
- Amphiphilic polymers,
- Amphiphilic supramolecules,
- Amphiphilic supramacromolecules
1. [1]
  Hocine, S.; Li, M. H. Thermoresponsive self-assembled polymer colloids in water. Soft Matter 2013, 9, 5839-5861. doi: 10.1039/c3sm50428j
2. [2]
  Blanazs, A.; Armes, S. P.; Ryan, A. J. Self-assembled block copolymer aggregates: From micelles to vesicles and their biological applications. Macromol. Rapid. Comm. 2009, 30, 267-77. doi: 10.1002/marc.v30:4/5
3. [3]
  Karami, Z.; Hamidi, M. Cubosomes: Remarkable drug delivery potential. Drug Discov. Today 2016, 21, 789-801. doi: 10.1016/j.drudis.2016.01.004
4. [4]
  Percec, V.; Wilson, D. A.; Leowanawat, P.; Wilson, C. J.; Hughes, A. D.; Kaucher, M. S.; Hammer, D. A.; Levine, D. H.; Kim, A. J.; Bates, F. S.; Davis, K. P.; Lodge, T. P.; Klein, M. L.; DeVane, R. H.; Aqad, E.; Rosen, B. M.; Argintaru, A. O.; Sienkowska, M. J.; Rissanen, K.; Nummelin, S.; Ropponen, J. Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures. Science 2010, 328, 1009-1014. doi: 10.1126/science.1185547
5. [5]
  Lombardo, D.; Kiselev, M. A.; Magazù, S.; Calandra, P. Amphiphiles self-Assembly: Basic concepts and future perspectives of supramolecular approaches. Adv. Cond. Matter Phys. 2015, 2015, 1-22.
6. [6]
  Discher, D. E.; Ahmed, F. Polymersomes. Annu. Rev. Biomed. Eng. 2006, 8, 323-341. doi: 10.1146/annurev.bioeng.8.061505.095838
7. [7]
  Ahmed, F.; Pakunlu, R. I.; Brannan, A.; Bates, F.; Minko, T.; Discher, D. E. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control Release. 2006, 116, 150-158. doi: 10.1016/j.jconrel.2006.07.012
8. [8]
  Eloy, J. O.; Claro de Souza, M.; Petrilli, R.; Barcellos, J. P. A.; Lee, R. J.; Marchetti, J. M. Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery. Colloids Surf. B 2014, 123, 345-363. doi: 10.1016/j.colsurfb.2014.09.029
9. [9]
  Antonietti, M.; Förster, S. Vesicles and liposomes: A self-assembly principle beyond lipids. Adv. Mater. 2003, 15, 1323-1333. doi: 10.1002/(ISSN)1521-4095
10. [10]
  Broz, P.; Benito, S. M.; Saw, C.; Burger, P.; Heider, H.; Pfisterer, M.; Marsch, S.; Meier, W.; Hunziker, P. Cell targeting by a generic receptor-targeted polymer nanocontainer platform. J. Control Release. 2005, 102, 475-488. doi: 10.1016/j.jconrel.2004.10.014
11. [11]
  Lin, Y. S.; Lee, M.-Y.; Yang, C. H.; Huang, K. S. Active targeted drug delivery for microbes using nano-carriers. Curr. Top. Med. Chem. 2015, 15, 1525-1531. doi: 10.2174/1568026615666150414123157
12. [12]
  De Oliveira, H.; Thevenot, J.; Lecommandoux, S. Smart polymersomes for therapy and diagnosis: Fast progress toward multifunctional biomimetic nanomedicines. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2012, 4, 525-546. doi: 10.1002/wnan.1183
13. [13]
  Deng, Y.; Ling, J.; Li, M. H. Physical stimuli-responsive liposomes and polymersomes as drug delivery vehicles based on phase transitions in the membrane. Nanoscale 2018, 10, 6781-6800. doi: 10.1039/C8NR00923F
14. [14]
  Li, M. H.; Keller, P. Stimuli-responsive polymer vesicles. Soft Matter 2009, 5, 927-937. doi: 10.1039/b815725a
15. [15]
  Mabrouk, E.; Cuvelier, D.; Brochard-Wyart, F.; Nassoy, P.; Li, M. H. Bursting of sensitive polymersomes induced by curling. Proc. Natl. Acad. Sci. U.S.A 2009, 106, 7294-7298. doi: 10.1073/pnas.0813157106
16. [16]
  Meng, F. H.; Zhong, Z. Y.; Feijen, J. Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10, 197-209. doi: 10.1021/bm801127d
17. [17]
  Du, J.; O'Reilly, R. K. Advances and challenges in smart and functional polymer vesicles. Soft Matter 2009, 3544-3561.
18. [18]
  Smart, T.; Lomas, H.; Massignani, M.; Flores-Merino, M. V.; Perez, L. R.; Battaglia, G. Block copolymer nanostructures. Nano Today 2008, 3, 38-46. doi: 10.1016/S1748-0132(08)70043-4
19. [19]
  Discher, B. M.; Bermudez, H.; Hammer, D. A.; Discher, D. E.; Won, Y. Y.; Bates, F. S. Cross-linked polymersome membranes: Vesicles with broadly adjustable properties. J. Phys. Chem. B 2002, 106, 2848-2854. doi: 10.1021/jp011958z
20. [20]
  Kikuchi, K. Design, synthesis and biological application of chemical probes for bio-imaging. Chem. Soc. Rev. 2010, 39, 2048-2053. doi: 10.1039/b819316a
21. [21]
  Haugland, R. P. in The molecular probes handbook: A guide to fluorescent probes and labeling technologies. Life Technologies: Carlsbad, CA, 2010.
22. [22]
  Liang, J.; Tang, B. Z.; Liu, B. Specific light-up bioprobes based on AIEgen conjugates. Chem. Soc. Rev. 2015, 44, 2798-2811. doi: 10.1039/C4CS00444B
23. [23]
  Zhang, X.; Zhang, X.; Tao, L.; Chi, Z.; Xu, J.; Wei, Y. Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications. J. Mater. Chem. B 2014, 2, 4398-4414.
24. [24]
  Yan, L.; Zhang, Y.; Xu, B.; Tian, W. Fluorescent nanoparticles based on AIE fluorogens for bioimaging. Nanoscale 2016, 8, 2471-2487. doi: 10.1039/C5NR05051K
25. [25]
  Li, K.; Liu, B. Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. Chem. Soc. Rev. 2014, 43, 6570-6597. doi: 10.1039/C4CS00014E
26. [26]
  Chen, M.; Yin, M. Design and development of fluorescent nanostructures for bioimaging. Prog. Polym. Sci. 2014, 39, 365-395. doi: 10.1016/j.progpolymsci.2013.11.001
27. [27]
  Ghoroghchian, P. P.; Frail, P. R.; Susumu, K.; Blessington, D.; Brannan, A. K.; Bates, F. S.; Chance, B.; Hammer, D. A.; Therien, M. J. Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging. Proc. Natl. Acad. Sci. 2005, 102, 2922-2927. doi: 10.1073/pnas.0409394102
28. [28]
  Kamat, N. P.; Liao, Z.; Moses, L. E.; Rawson, J.; Therien, M. J.; Dmochowski, I. J.; Hammer, D. A. Sensing membrane stress with near IR-emissive porphyrins. Proc. Natl. Acad. Sci. 2011, 108, 13984-13989. doi: 10.1073/pnas.1102125108
29. [29]
  Duncan, T. V.; Ghoroghchian, P. P.; Rubtsov, I. V.; Hammer, D. A.; Therien, M. J. Ultrafast excited-state dynamics of nanoscale near-infrared emissive polymersomes. J. Am. Chem. Soc. 2008, 130, 9773-9784. doi: 10.1021/ja711497w
30. [30]
  Christian, N. A.; Benencia, F.; Milone, M. C.; Li, G.; Frail, P. R.; Therien, M. J.; Coukos, G.; Hammer, D. A. In vivo dendritic cell tracking using fluorescence lifetime imaging and near-infrared-emissive polymersomes. Mol. Imaging Biol. 2009, 11, 167-177. doi: 10.1007/s11307-008-0184-x
31. [31]
  Birks, J. B. in Photophysics of aromatic molecules. Wiley, New York, 1970.
32. [32]
  Luo, J.; Xie, Z.; Lam, J. W. Y.; Cheng, L.; Chen, H.; Qiu, C.; Kwok, H. S.; Zhan, X.; Liu, Y.; Zhu, D.; Tang, B. Z. Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chem. Commun. 2001, 0, 1740-1741.
33. [33]
  Mei, J.; Leung, N. L.; Kwok, R. T.; Lam, J. W.; Tang, B. Z. Aggregation-induced emission: together we shine, united we soar! Chem. Rev. 2015, 115, 11718-11940.
34. [34]
  Mei, J.; Hong, Y.; Lam, J. W. Y.; Qin, A.; Tang, Y.; Tang, B. Z. Aggregation-induced emission: the whole is more brilliant than the parts. Adv. Mater. 2014, 26, 5429-5479. doi: 10.1002/adma.201401356
35. [35]
  Ding, D.; Li, K.; Liu, B.; Tang, B. Z. Bioprobes based on AIE fluorogens. Acc. Chem. Res. 2013, 46, 2441-2453. doi: 10.1021/ar3003464
36. [36]
  Huang, J.; Yu, Y.; Wang, L.; Wang, X.; Gu, Z.; Zhang, S. Tetraphenylethylene-induced cross-linked vesicles with tunable luminescence and controllable stability. ACS Appl. Mater. Interfaces 2017, 9, 29030-29037. doi: 10.1021/acsami.7b06954
37. [37]
  Nonappa; Maitra, U. Unlocking the potential of bile acids in synthesis, supramolecular/materials chemistry and nanoscience. Org. Biomol. Chem. 2008, 6, 657-669. doi: 10.1039/b714475j
38. [38]
  Zhang, M.; Yin, X.; Tian, T.; Liang, Y.; Li, W.; Lan, Y.; Li, J.; Zhou, M.; Ju, Y.; Li, G. AIE-induced fluorescent vesicles containing amphiphilic binding pockets and the FRET triggered by host-guest chemistry. Chem. Commun. 2015, 51, 10210-10213. doi: 10.1039/C5CC02377G
39. [39]
  Dan, N., in Nanostructures for drug delivery, core-shell drug carriers: Liposomes, polymersomes, and niosomes. Elsevier, 2017, pp 63−105.
40. [40]
  Wang, X.; Yang, Y.; Zhuang, Y.; Gao, P.; Yang, F.; Shen, H.; Guo, H.; Wu, D. Fabrication of pH-responsive nanoparticles with an AIE feature for imaging intracellular drug delivery. Biomacromolecules 2016, 17, 2920-2929. doi: 10.1021/acs.biomac.6b00744
41. [41]
  Wang, X.; Yang, Y.; Zuo, Y.; Yang, F.; Shen, H.; Wu, D. Facile creation of FRET systems from a pH-responsive AIE fluorescent vesicle. Chem. Commun. 2016, 52, 5320-5323. doi: 10.1039/C6CC01706A
42. [42]
  Wang, X.; Yang, Y.; Yang, F.; Shen, H.; Wu, D. pH-triggered decomposition of polymeric fluorescent vesicles to induce growth of tetraphenylethylene nanoparticles for long-term live cell imaging. Polymer 2017, 118, 75-84. doi: 10.1016/j.polymer.2017.04.064
43. [43]
  Li, G.; Du, F.; Wang, H.; Bai, R. Synthesis and self-assembly of carbazole-based amphiphilic triblock copolymers with aggregation-induced emission enhancement. React. Funct. Polym. 2014, 75, 75-80.. doi: 10.1016/j.reactfunctpolym.2013.12.007
44. [44]
  Ma, C. P.; Chi, Z. G.; Zhou, X.; Zhang, Y.; Liu, S. W.; Xu, J. R. AIE vesicles consisting of tetraphenylethylene-based amphiphilic diblock copolymer with a poly(N-isopropylacrylamide) sequence. J. Control Release. 2013, 172, e95.
45. [45]
  Zhao, Y.; Wu, Y.; Yan, G.; Zhang, K. Aggregation-induced emission block copolymers based on ring-opening metathesis polymerization. RSC Adv. 2014, 4, 51194-51200. doi: 10.1039/C4RA08191A
46. [46]
  Zhao, Y.; Zhu, W.; Ren, L.; Zhang, K. Aggregation-induced emission polymer nanoparticles with pH-responsive fluorescence. Polym. Chem. 2016, 7, 5386-5395. doi: 10.1039/C6PY01009A
47. [47]
  Zhang, N.; Chen, H.; Fan, Y.; Zhou, L.; Trepout, S.; Guo, J.; Li, M. H. Fluorescent polymersomes with aggregation-induced emission. ACS Nano 2018, 12, 4025-4035. doi: 10.1021/acsnano.8b01755
48. [48]
  Liu, Q.; Xia, Q.; Wang, S.; Li, B. S.; Tang, B. Z. In situ visualizable self-assembly, aggregation-induced emission and circularly polarized luminescence of tetraphenylethene and alanine-based chiral polytriazole. J. Mater. Chem. C 2018, 6, 4807-4816. doi: 10.1039/C8TC00838H
49. [49]
  Wang, C.; Wang, Z. Q.; Zhang, X. Amphiphilic building blocks for self-assembly: From amphiphiles to supra-amphiphiles. Acc. Chem. Res. 2012, 45, 608-618. doi: 10.1021/ar200226d
50. [50]
  Zhang, X.; Wang, C. Supramolecular amphiphiles. Chem. Soc. Rev. 2011, 40, 94-101. doi: 10.1039/B919678C
51. [51]
  Chen, L. J.; Ren, Y.-Y.; Wu, N. W.; Sun, B.; Ma, J. Q.; Zhang, L.; Tan, H.; Liu, M.; Li, X.; Yang, H. B. Hierarchical self-assembly of discrete organoplatinum(II) metallacycles with polysaccharide via electrostatic interactions and their application for heparin detection. J. Am. Chem. Soc. 2015, 137, 11725-11735. doi: 10.1021/jacs.5b06565
52. [52]
  Zheng, W.; Yang, G.; Jiang, S.-T.; Shao, N.; Yin, G.-Q.; Xu, L.; Li, X.; Chen, G.; Yang, H.-B. A tetraphenylethylene (TPE)-based supra-amphiphilic organoplatinum(II) metallacycle and its self-assembly behaviour. Mater. Chem. Front. 2017, 1, 1823-1828. doi: 10.1039/C7QM00107J
53. [53]
  Zhang, C. W.; Ou, B.; Jiang, S. T.; Yin, G. Q.; Chen, L. J.; Xu, L.; Li, X.; Yang, H. B. Cross-linked AIE supramolecular polymer gels with multiple stimuli-responsive behaviours constructed by hierarchical self-assembly. Polym. Chem. 2018, 9, 2021-2030. doi: 10.1039/C8PY00226F
54. [54]
  Chi, X.; Zhang, H.; Vargas-Zuniga, G. I.; Peters, G. M.; Sessler, J. L. A Dual-responsive bola-type supra-amphiphile constructed from a water-soluble calix[4] pyrrole and a tetraphenylethene-containing pyridine bis-N-oxide. J. Am. Chem. Soc. 2016, 138, 5829-5832. doi: 10.1021/jacs.6b03159
55. [55]
  Li, J.; Shi, K.; Drechsler, M.; Tang, B. Z.; Huang, J.; Yan, Y. A supramolecular fluorescent vesicle based on a coordinating aggregation induced emission amphiphile: Insight into the role of electrical charge in cancer cell division. Chem. Commun. 2016, 52, 12466-12469. doi: 10.1039/C6CC06432A
56. [56]
  Li, J.; Liu, K.; Chen, H.; Li, R.; Drechsler, M.; Bai, F.; Huang, J.; Tang, B. Z.; Yan, Y. Functional built-in template directed siliceous fluorescent supramolecular vesicles as diagnostics. ACS Appl. Mater. Interfaces 2017, 9, 21706-21714. doi: 10.1021/acsami.7b06306
57. [57]
  Li, J.; Liu, K.; Han, Y.; Tang, B. Z.; Huang, J.; Yan, Y. Fabrication of propeller-shaped supra-amphiphile for construction of enzyme-responsive fluorescent vesicles. ACS Appl. Mater. Interfaces 2016, 8, 27987-27995. doi: 10.1021/acsami.6b08620
58. [58]
  Wei, Y.; Wang, L.; Huang, J.; Zhao, J.; Yan, Y. Multifunctional metallo-organic vesicles displaying aggregation-Induced emission: two-photon cell-Imaging, drug delivery, and specific detection of zinc ion. ACS Appl. Nano Mater. 2018, 1, 1819-1827. doi: 10.1021/acsanm.8b00226
59. [59]
  Kong, Q.; Zhuang, W.; Li, G.; Jiang, Q.; Wang, Y. Cation-anion interaction-directed formation of functional vesicles and their biological application for nucleus-specific imaging. New J. Chem. 2018, 42, 9187-9192. doi: 10.1039/C8NJ01503A
60. [60]
  He, L.; Liu, X.; Liang, J.; Cong, Y.; Weng, Z.; Bu, W. Fluorescence responsive conjugated poly(tetraphenylethene) and its morphological transition from micelle to vesicle. Chem. Commun. 2015, 51, 7148-7151. doi: 10.1039/C5CC00934K
61. [61]
  Ji, X. F.; Li, Y.; Wang, H.; Zhao, R.; Tangb, G. P.; Huang, F. H. Facile construction of fluorescent polymeric aggregates with various morphologies by self-assembly of supramolecular amphiphilic graft copolymers. Polym. Chem. 2015, 6, 5021-5025. doi: 10.1039/C5PY00801H
62. [62]
  Shen, J.; Pang, J.; Xu, G.; Xin, X.; Yang, Y.; Luan, X.; Yuan, S. Smart stimuli-responsive fluorescent vesicular sensor based on inclusion complexation of cyclodextrins with Tyloxapol. RSC Adv. 2016, 6, 11683-11690. doi: 10.1039/C5RA26464B
63. [63]
  Shen, J.; Wang, Z.; Sun, D.; Xia, C.; Yuan, S.; Sun, P.; Xin, X. pH-responsive nanovesicles with enhanced emission co-assembled by Ag(I) nanoclusters and polyethyleneimine as a superior sensor for Al³⁺. ACS Appl. Mater. Interfaces 2018, 10, 3955-3963. doi: 10.1021/acsami.7b16316
64. [64]
  Zhang, X.; Rehm, S.; Safont-Sempere, M. M.; Würthner, F. Vesicular perylene dye nanocapsules as supramolecular fluorescent pH sensor systems. Nat. Chem. 2009, 1, 623-629. doi: 10.1038/nchem.368
65. [65]
  Sapsford, K. E.; Berti, L.; Medintz, I. L. Fluorescence resonance energy transfer - Concepts, applications and advances. Minerva. Biotecnol. 2004, 16, 247-273.
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