Citation: Man-Zhu Zhao, Dong-Bing Cheng, Zhao-Ru Shang, Lei Wang, Zeng-Ying Qiao, Jing-Ping Zhang, Hao Wang. An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications[J]. Chinese Journal of Polymer Science, ;2018, 36(10): 1103-1113. doi: 10.1007/s10118-018-2170-3 shu

An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications

Man-Zhu Zhao ^1,2,† ,
Dong-Bing Cheng ^2,† ,
Zhao-Ru Shang ² ,
Lei Wang ² ,
Zeng-Ying Qiao ² ,
Jing-Ping Zhang ^1,, ,
Hao Wang ^2,,

a.
School of Chemistry, Northeast Normal University, Changchun 130024, China
b.
Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China

Corresponding author: Jing-Ping Zhang, zhangjp162@nenu.edu.cn Hao Wang, wanghao@nanoctr.cn
Received Date: 18 May 2018
Revised Date: 10 June 2018
Accepted Date: 12 June 2018
Available Online: 11 July 2018

The interfacing study of biopolymer and supramolecular chemistry enables a better understanding of fundamental biochemical processes and the creating of new high-performance biomaterials. In this review, we introduced an " in vivo self-assembly” strategy which means in situ construction of functional self-assembled superstructures in specific physiological or pathological conditions in cell, tissue or animal levels that exhibit diverse biomedical effects. By using this strategy, unexpected phenomena and insights, e.g, assembly/aggregation induced retention (AIR) effect have been demonstrated where the self-assembled nanostructures showed extraordinary enhanced accumulation and retention of therapeutics in targeted sites.
- In vivo self-assembly,
- Supramolecular polymer,
- Therapy,
- Imaging
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