Citation: Hao Tang, Jin Tang, Yi Shen, Wen-Xuan Guo, Min Zhou, Rui-Hua Wang, Ni Jiang, Zhi-Hua Gan, Qing-Song Yu. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties[J]. Chinese Journal of Polymer Science, ;2018, 36(11): 1225-1238. doi: 10.1007/s10118-018-2159-y shu

Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties

Hao Tang ^1,2 ,
Jin Tang ^1,2 ,
Yi Shen ^1,2 ,
Wen-Xuan Guo ^1,2 ,
Min Zhou ^1,2 ,
Rui-Hua Wang ^1,2 ,
Ni Jiang ^1,2 ,
Zhi-Hua Gan ^1,2,3,, ,
Qing-Song Yu ^1,2,,

a.
The State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
b.
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
c.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China

Corresponding author: Zhi-Hua Gan, zhgan@mail.buct.edu.cn Qing-Song Yu, yuqs@mail.buct.edu.cn
Received Date: 18 April 2018
Revised Date: 14 May 2018
Accepted Date: 15 May 2018
Available Online: 30 June 2018

The synthesis and structure-property correlation of poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA) conjugates with various architectures including random, block, branched or star-like structures and compositions have been thoroughly explored. However, related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work, we report the synthesis of comb-like PHPMA copolymer-doxorubicin (DOX) conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained via the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake, blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number, length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation.
- Poly(N-(2-hydroxypropyl) methacrylamide),
- Comb-like copolymer,
- Anticancer drug delivery,
- Synthesis,
- Structure-property correlation
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沈阳化工大学材料科学与工程学院沈阳 110142