Citation: Yan-Ling Xu, Ao-Ting Qu, Ru-Jiang Ma, Ang Li, Zhen-Kun Zhang, Zhi-Qiang Shang, Yao-Fang Zhang, Lu-Xia Bu, Ying-Li An. pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation[J]. Chinese Journal of Polymer Science, ;2018, 36(11): 1262-1268. doi: 10.1007/s10118-018-2149-0 shu

pH-responsive Micelles from a Blend of PEG-b-PLA and PLA-b-PDPA Block Copolymers: Core Protection Against Enzymatic Degradation

a.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China
b.
College of Basic Science, Chemistry Experiment Teaching Center, Tianjin Agricultural University, Tianjin 300384, China

Corresponding author: Ying-Li An, anyingli@nankai.edu.cn
Received Date: 4 March 2018
Revised Date: 25 April 2018
Accepted Date: 16 May 2018
Available Online: 14 June 2018

pH-responsive micelles with a biodegradable PLA core and a mixed PEG/PDPA shell were prepared by self-assembly of poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA) and poly(2-(diisopropylamino)ethyl methacrylate)-b-poly(lactic acid) (PDPA-b-PLA). The micellization status with different pH and the enzyme degradation behavior were characterized by ¹H-NMR spectroscopy, dynamic light scattering measurement and zeta potential test. The pH turning point of PDPA block was determined to be in the range of 5.5−7.0. While the pH was above 7.0, the PDPA block collapsed onto the PLA core and could protect the PLA core from invasion of enzyme, as a result, the micelle exhibited a resistance to the enzymatic degradation.
- pH-responsive,
- Enzymatic degradation,
- Poly(lactic acid)
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沈阳化工大学材料科学与工程学院沈阳 110142