Citation: Xiao-jiu Liu, Ye-min Zhang, Xin-song Li. Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach[J]. Chinese Journal of Polymer Science, ;2015, 33(12): 1741-1749. doi: 10.1007/s10118-015-1717-9 shu

Tough Biopolymer IPN Hydrogel Fibers by Bienzymatic Crosslinking Approach

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School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210018, China

Corresponding author: Xin-song Li,
Received Date: 28 May 2015
Revised Date: 18 June 2015

Fund Project: This work was financially supported by the National Natural Science Foundation of China(Nos.51373034 and 51073036).

In this report, bienzymatic crosslinking approach was applied to prepare biopolymer hydrogel fibers composed of gelatin and chitosan with an interpenetrating polymer network(IPN) structure. The IPN biopolymer hydrogel fibers were prepared by wet spinning while microbial transglutaminase(mTG) catalyzed the formation of one network of gelatin and horseradish peroxidase(HRP) in the presence of H2O2 induced another network of chitosan grafted with phloretic acid(chitosan-PA) intertwining with the former. The mechanical performances of the hydrogel fibers were measured by an electronic single fiber strength tester. It was found that the mechanical properties of the gelatin/chitosan IPN hydrogel fibers had a significant improvement with the increase of the concentration of gelatin and chitosan, and the IPN fiber has the highest tension of 38.6 cN and elongation of 387.2%. Accelerated degradation in the presence of papin indicated that the gelatin/chitosan-PA IPN hydrogel fibers own controllable degradability. In addition, biological evaluation indicated the IPN hydrogel fibers can support cell adhesion and proliferation. Moreover, hand weaving trail showed the knittablity of the IPN hydrogel fibers. Therefore, the gelatin/chitosan IPN hydrogel fibers prepared by bienzymatic crosslinking approach possess excellent biocompatibility and mechanical strength, which may be desirable candidates for engineering tissue scaffolds.
- Hydrogel fiber,
- Bienzymatic crosslinking,
- Gelatin,
- Interpenetrating polymer network,
- Mechanical strength
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沈阳化工大学材料科学与工程学院沈阳 110142