Citation: Chi Wu. How Does a Polymer Brush Repel Proteins?[J]. Chinese Journal of Polymer Science, ;2014, 32(11): 1575-1580. doi: 10.1007/s10118-014-1539-1 shu

How Does a Polymer Brush Repel Proteins?

Chi Wu ^1,,

Corresponding author: Chi Wu, chiwu.cuhk@gmail.com
Received Date: 1 August 2014
Revised Date: 17 August 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51173177 and 51273091), the Ministry of Science and Technology of China Key Project (2012CB933802), and the Hong Kong Special Administration Region Earmarked Projects (CUHK4036/11P, 2130281 and 2060431 CUHK4035/12P, 2130306 and 4053005 and CUHK7/CRF/12G, 2390062).

The captioned question has been addressed by the steric effect; namely, the adsorption of proteins on a surface grafted with linear polymer chains decreases monotonically as the grafting density increases. However, there is no quantitative and satisfactory explanation why the adsorption starts to increase when the grafting density is sufficiently high and why polyethylene glycol (PEG) still remains as one of the best polymers to repel proteins. After considering each grafted chain as a molecular spring confined inside a tube made of its surrounding grafted chains, we estimated how its free energy depends on the grafting density and chain length, and calculated its thermal energy-agitated chain conformation fluctuation, enabling us to predict an adsorption minimum at a proper grafting density, which agrees well with previous experimental results. We propose that it is such a chain fluctuation that slows down the adsorption kinetically.
- Polymer brush,
- Protein adsorption,
- Antifouling
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