Citation: Wen Zeng, Wei-kang Hu, Hao Li, Yi-han Jing, Hua Kang, Qing Jiang, Chao Zhang. Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds[J]. Chinese Journal of Polymer Science, ;2014, 32(11): 1507-1514. doi: 10.1007/s10118-014-1536-4 shu

Preparation and Characterization of Poly(-glutamic acid) Hydrogels as Potential Tissue Engineering Scaffolds

Wen Zeng ¹ ,
Wei-kang Hu ¹ ,
Hao Li ¹ ,
Yi-han Jing ¹ ,
Hua Kang ¹ ,
Qing Jiang ¹ ,
Chao Zhang ^1,,

1.
School of Engineering, Sun Yat-sen University, Guangdong 510006, China

Corresponding author: Chao Zhang,
Received Date: 13 January 2014
Revised Date: 24 March 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 21004080), the Program for New Century Excellent Talents in Universities (No. NCET-09-0818) of the Ministry of Education of China, and the Fundamental Research Funds for the Central Universities (No.101GPY41).

In this paper, methacrylated -PGA (mPGA) precursor was synthesized via reaction between -PGA and glycidyl methacrylate (GMA). Hydrogels from this precursor were prepared under 365 nm ultraviolet irradiation. The swelling behavior and mechanical properties were studied in detail as functions of the degree of substitution (DS), precursor concentration, and environmental pH. Results showed that the crosslink density, swelling kinetics and mechanical properties of the hdyrogel could be tailored by adjusting the DS and concentration of the precursor as well as the environmental pH. Three-dimensional photo-encapsulation of swine cartilage chondrocytes and Live/Dead assay proved the cytocompatibility of the hydrogel.
- Poly(,
- -glutamic) acid,
- Hydrogel,
- Tissue engineering scaffold
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