Citation: Hua-jie Li, Zhong Yu, Shuang-ping Wang, Li-ming Zhang, Li-qun Yang. Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles[J]. Chinese Journal of Polymer Science, ;2014, 32(10): 1413-1418. doi: 10.1007/s10118-014-1517-7 shu

Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles

1.
Institute of Polymer Science, School of Chemistry and Chemical Engineering, Key Laboratory of Designed Synthesis and Application of Polymer Material, Key Laboratory for Polymeric Composites and Functional Materials of Ministry of Education, Sun Yat-Sen University, Guangzhou 510275, China
2.
Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

Corresponding author: Li-qun Yang,
Received Date: 14 March 2014
Revised Date: 2 July 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 21244005 and 20974130), and the Science and Technology Planning Project of Guangdong Province, China (No. 2012B091100356).

Photosensitizer (photosan)-encapsulated micelles were prepared by self-assembly of Photosan with two amphiphilic polysaccharide derivatives, including the cholesteryl conjugated sodium alginate derivative (CSAD) and the deoxycholic acid group conjugated chitosan derivative (DA-Chit). The results of UV-Vis and fluorescence spectroscopy indicated that the hydrogen bonding strength dominated the micelle formation. Methyl viologen was used as a model quencher of photosan. Using the steady-state fluorescence technology, the quenching constants were determined to be 2.05, 1.88 and 0.30 L/mmol for the free photosan, the photosan-CSAD micelle and the photosan-DA-Chit micelle, respectively. This suggested that photosan was protected from quenching of methyl viologen by the polysaccharide micelles. In addition, the protection effect of the photosan-DA-Chit micelle was significantly stronger than that of the photosan-CSAD micelle. The photosan-DA-Chit micelle is thus anticipated for protection of photoactivity of photosan during the blood circulation process in vivo.
- Chitosan,
- Sodium alginate,
- Photosensitizer,
- Photoactivity,
- Quenching
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