源起于发霉甜苜蓿，脱胎于生化实验室，华法林先生起初作为一种强力灭鼠毒药大杀四方。然而，在进入医药领域的道路上，他却因毒药的身份标签和种种流言而饱受质疑和反对。科学家们揭示了华法林抗凝血的机制，并证明了华法林抗凝治疗对患者的益处。从此，华法林先生以及他的衍生物们成为了抗凝治疗和防治鼠害的前线战士。

The selective hydrogenation of α, β-unsaturated aldehydes/ketones enables precise control over product structures and properties by regulating hydrogen transport pathways and bond cleavage sequences to selectively reduce C=C or C=O bonds while preserving other functional groups within the molecule. This approach serves as a critical strategy for the directional synthesis of high-value molecules. However, achieving such selectivity remains challenging due to the thermodynamic equilibrium and kinetic competition between C=O and C=C bonds in α, β-unsaturated systems. Consequently, constructing precisely targeted catalytic systems is essential to overcome these limitations, offering both fundamental scientific significance and industrial application potential. Metal-organic frameworks (MOFs) and their derivatives have emerged as innovative platforms for designing such systems, owing to their programmable topology, tunable pore microenvironments, spatially controllable active sites, and modifiable electronic structures. This review systematically summarizes the research progress of MOF-based catalysts for selective hydrogenation of α, β-unsaturated aldehydes/ketones in the last decade, with emphasis on the design strategy, conformational relationship, and catalytic mechanism, aiming to provide new ideas for the design of targeted catalytic systems for the selective hydrogenation of α, β-unsaturated aldehydes/ketones.