法林:从毒药到良方
方洲, 张致豪, 蒋炜涵, 陈建成
【大学化学】doi: 10.12461/PKU.DXHX202406038
源起于发霉甜苜蓿,脱胎于生化实验室,华法林先生起初作为一种强力灭鼠毒药大杀四方。然而,在进入医药领域的道路上,他却因毒药的身份标签和种种流言而饱受质疑和反对。科学家们揭示了华法林抗凝血的机制,并证明了华法林抗凝治疗对患者的益处。从此,华法林先生以及他的衍生物们成为了抗凝治疗和防治鼠害的前线战士。
关键词: 抗凝药物, 双香豆素, 维生素K, 维生素K环氧化物还原酶
Dual‐surface capped hydroxyapatite nano‐amendment with tuned alternate long‐short chain configuration for efficient adsorption towards multi‐heavy metal ions in complex‐contaminated systems
Mochou GAO, Shan MENG, Jinzhong ZHANG, Wenhua FENG, Shuo DONG, Jianping CHEN, Yanbao ZHAO, Laigui YU, Rongrong YING, Xueyan ZOU
【无机化学学报】doi: 10.11862/CJIC.20240431
Hydroxyapatite nanoparticles (HAP NPs) were synthesized by a one‐step hydrothermal method. The surface of HAP NPs was grafted —SH and —COOH chelating groups via in situ surface‐modification with iminodiacetic acid (IDA) and 3‐mercaptopropyl trimethoxysilane (MPS) to afford dual surface‐capped nano‐amendment HAP‐IDA/MPS. The structure of HAP‐IDA/MPS was characterized, and its adsorption performance for Hg2+, Cu2+, Zn2+, Ni2+, Co2+, and Cd2+ was evaluated. The total adsorption capacity of 0.10 g HAP‐IDA/MPS nano‐amendment for Hg2+, Cu2+, Zn2+, Ni2+, Co2+, and Cd2+ with an initial mass concentration of 20 mg·L-1 reached 13.7 mg·g-1, about 4.3 times as much as that of HAP. Notably, HAP‐IDA/MPS nano‐amendment displayed the highest immobilization rate for Hg2+, possibly because of its chemical reaction with —SH to form sulfide, possessing the lowest solubility product constant among a variety of metal sulfides.
关键词: heavy metal, hydroxyapatite, nano‐amendment, configuration tuning, synergistic adsorption

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