从教学改革的角度出发，通过增加自主设计实验来促进学生的自主学习能力和实验设计思维能力的提升。自主设计实验要求学生自主查阅文献、设计实验方案、分析方案可行性、实验探究后进行综合讨论分析。进一步培养学生独立思考、融会贯通的能力，培养查阅文献、撰写实验方案的能力，为将来的科学研究工作打下坚实基础。

为全面深化信息技术与实验教学的融合，推进化学实验课堂的改革与创新，本文从信息化教学视角出发，借助虚拟仿真技术，开展了以“甘氨酸合铜的制备及其差热分析”为例的双线混融实验教学模式研究，实现了化学实验教学课堂从封闭到开放的转变，构建“过程–结果”二维度，“虚拟与真实、理论与操作、线上与线下”三结合，实施“课前网上预习–课中实验操作–课后总结分析”全过程的多元化实验教学评价方法，培养学生自主学习和实践探索能力，实现从预成性知识到建构性知识的转变。

为培养学生的科研思维及创新能力，加深学生对无机簇合物概念及荧光性能的认识与理解，设计开发了铜碘簇合物的制备及荧光检测亚硝酸盐的综合性实验。利用纳米沉淀的方法合成铜碘簇合物，通过红外光谱、X射线粉末衍射、扫描电子显微镜、紫外光谱、荧光光谱等分析手段对材料进行结构及性能表征，考察材料的荧光及检测亚硝酸盐的性能。结果表明：材料对亚硝酸盐具有高选择、高灵敏检测，检出限为3.73 µmol∙L⁻¹，可作为监测亚硝酸盐的“开-关”荧光探针。通过该实验，学生不仅对簇合物的结构及荧光分析法检测亚硝酸盐等前沿知识加深理解，还可学习紫外分析仪、荧光分光光度计等仪器的基本原理及操作技能，为将来从事相关科研及工作奠定基础。

To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects, the new anthraquinone derivatives, 9-pyridylanthrahydrazone (9-PAH) and 9, 10-bispyridylanthrahydrazone (9, 10-PAH) were designed and synthesized. Utilizing 9-PAH and 9, 10-PAH as promising anticancer ligands, their respective copper complexes, namely [Cu(L1)Cl₂]Cl (1) and {[Cu₄(μ₂-Cl)₃Cl₄(9, 10-PAH)₂(DMSO)₂]Cl₂}_n (2), were subsequently synthesized, where the new ligand L1 is formed by coupling two 9-PAH ligands in the coordination reaction. The chemical and crystal structures of 1 and 2 were elucidated by IR, MS, elemental analysis, and single-crystal X-ray diffraction. Complex 1 forms a mononuclear structure. L1 coordinates with Cu through its three N atoms, together with two Cl atoms, to form a five-coordinated square pyramidal geometry. Complex 2 constitutes a polymeric structure, wherein each structural unit centrosymmetrically encompasses two five-coordinated binuclear copper complexes (Cu1, Cu2) of 9, 10-PAH, with similar square pyramidal geometry. A chlorine atom (Cl2), located at the symmetry center, bridges Cu1 and Cu1A to connect the two binuclear copper structures. Meanwhile, the two five-coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom, respectively, thus forming a 1D chain-like polymeric structure. In vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than cisplatin. Specifically, the IC₅₀ values of 2 against HeLa-229 and SK-OV-3 cancer cell lines were determined to be (5.92±0.32) μmol·L^-1 and (6.48±0.39) μmol·L^-1, respectively. 2 could also block the proliferation of HeLa-229 cells in S phase and significantly induce cell apoptosis. In addition, fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode, offering insights into its underlying anticancer mechanism.

在水热条件下，以硫酸锰为金属源，1-萘甲酸(Hna)、4,4'-二甲基-2，2'-联吡啶(Dmbpy)为配体合成了一例锰配合物[Mn (na)₂(Dmbpy)(H₂O)]·Hna (1)，并通过元素分析、单晶X射线衍射、粉末X射线衍射、红外光谱、Hirshfeld表面分析和热重分析进行了表征。单晶X射线衍射结果表明：1属三斜晶系$P \overline{1}$空间群，中心金属Mn(Ⅱ)位于六配位扭曲的三棱柱构型中，分子间通过C/O—H···O、C—H···π和π···π相互作用形成二维超分子网状结构。利用CrystalExplorer对1的Hirshfeld表面进行了分析。固态荧光光谱显示，1在347 nm的激发波长下，最大发射波长为423 nm。在荧光传感实验中，1对Fe³⁺表现出选择性识别的能力，检出限为0.52 μmol·L^-1，此外还探究了Fe³⁺猝灭1的荧光的机理。