Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl) quinolone derivatives

• Xin Guo ^a,b, ,
• Yi Liang Li ^a,c, ,
• Yu Fei Liu ^b, ,
• Hui Yuan Guo ^a, ,
• Yu Cheng Wang ^a,

• a Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;

• b College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;

• c Tianjin Institute of Pharmaceutical Research, Tianjin Key Laboratory of Molecular Design & Drug Discovery, Tianjin 300193, China;

• d Xuzhou Medical College, Xuzhou 221004, China

• Received Date: 25 February 2010
  
• Fund Project:

  This work was supported by the National Major Science and Technology Project of China ("Innovation and Development of New Drugs",No.2009ZX09301-003).