引用本文:
Di Zao Li, Yan Li, Xiao Guang Chen, Chen Gen Zhu, Jing Yang, Hong Yan Liu, Xian Dao Pan. Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins[J]. Chinese Chemical Letters,
2007, 18(11): 1335-1338.
doi:
10.1016/j.cclet.2007.09.014
Citation: Di Zao Li, Yan Li, Xiao Guang Chen, Chen Gen Zhu, Jing Yang, Hong Yan Liu, Xian Dao Pan. Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins[J]. Chinese Chemical Letters, 2007, 18(11): 1335-1338. doi: 10.1016/j.cclet.2007.09.014
Citation: Di Zao Li, Yan Li, Xiao Guang Chen, Chen Gen Zhu, Jing Yang, Hong Yan Liu, Xian Dao Pan. Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins[J]. Chinese Chemical Letters, 2007, 18(11): 1335-1338. doi: 10.1016/j.cclet.2007.09.014
Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins
摘要:
A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 possessed the best efficacy on six human cancer cell lines in the six classes of CPTs' derivatives. In vivo testing results indicated that 9 had better antitumor activity against mouse liver carcinoma H22 than topotecan.
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关键词:
- Camptothecin
- / Synthesis
- / Heterocyclic acid
- / Antitumor activity
English
Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins
Abstract:
A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 possessed the best efficacy on six human cancer cell lines in the six classes of CPTs' derivatives. In vivo testing results indicated that 9 had better antitumor activity against mouse liver carcinoma H22 than topotecan.
-
Key words:
- Camptothecin
- / Synthesis
- / Heterocyclic acid
- / Antitumor activity
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