引用本文:
Zhi Quan YONG, Xiao Ping XU, Ying Chun CHEN, Xu BAO, Ling Ling WENG, Hu ZHENG. Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4[J]. Chinese Chemical Letters,
2006, 17(1): 23-26.
Citation: Zhi Quan YONG, Xiao Ping XU, Ying Chun CHEN, Xu BAO, Ling Ling WENG, Hu ZHENG. Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4[J]. Chinese Chemical Letters, 2006, 17(1): 23-26.
Citation: Zhi Quan YONG, Xiao Ping XU, Ying Chun CHEN, Xu BAO, Ling Ling WENG, Hu ZHENG. Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4[J]. Chinese Chemical Letters, 2006, 17(1): 23-26.
Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4
摘要:
Novel water-soluble prodrugs of combretastatin A-4(5-8) were synthesized and evaluated for their in vitro cytotoxicity against lung carcinoma A549. Compound 5, bearing phosphoryl choline (PC) moiety, showed 90% inhibition at 32μg/mL concentration after 24 h. The findings showed the PC derivative would be a promising candidate for the development of new water-soluble prodrug of cytotoxic combretastatin A-4.
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关键词:
- Combretastatin A-4
- / cytotoxicity
- / phosphoryl choline
- / water-soluble
- / prodrug
English
Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4
Abstract:
Novel water-soluble prodrugs of combretastatin A-4(5-8) were synthesized and evaluated for their in vitro cytotoxicity against lung carcinoma A549. Compound 5, bearing phosphoryl choline (PC) moiety, showed 90% inhibition at 32μg/mL concentration after 24 h. The findings showed the PC derivative would be a promising candidate for the development of new water-soluble prodrug of cytotoxic combretastatin A-4.
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Key words:
- Combretastatin A-4
- / cytotoxicity
- / phosphoryl choline
- / water-soluble
- / prodrug
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