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糖蛋白质组学中基于化学反应的富集方法研究进展

包慧敏 ,  谢力琦 ,  陆豪杰

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引用本文: 包慧敏,  谢力琦,  陆豪杰. 糖蛋白质组学中基于化学反应的富集方法研究进展[J]. 色谱, 2016, 34(12): 1145-1153. doi: 10.3724/SP.J.1123.2016.09003 shu
Citation:  BAO Huimin,  XIE Liqi,  LU Haojie. Research advances of enrichment approaches based on chemical reactions in glycoproteomics[J]. Chinese Journal of Chromatography, 2016, 34(12): 1145-1153. doi: 10.3724/SP.J.1123.2016.09003 shu

糖蛋白质组学中基于化学反应的富集方法研究进展

  • 复旦大学化学系, 生物医学研究院和老年医学研究中心 上海 200433

  • 基金项目:

    国家重点研发项目（2016YFA0501303）；国家自然科学基金（20905014，21335002）；上海市自然科学基金（14ZR1403600）；上海市老-医学临床重点实验室建设项目（13dz2260700）.

摘要: 蛋白质糖基化是一种广泛存在的重要的蛋白质翻译后修饰，糖基化肽在总酶解肽中占的比例不超过5%，这使得糖肽的分离富集成为糖蛋白质组学研究发展的关键技术之一。在诸多糖蛋白质组富集技术中，化学方法是富集技术的主导，本文从化学反应的角度介绍糖基化蛋白质富集的技术进展。富集过程按照连接和释放分别讨论，在连接过程中，重点介绍硼酸化学法、肼化学法、胺化学法和肟点击法；在释放过程中，以N-糖蛋白的酶释放法和O-糖蛋白的β-消除法为主导，一并介绍了最新的氧化断裂释放的化学法。最后，讨论总体富集策略的发展现状。该文以糖蛋白富集的共价反应为核心，分析不同方法的优缺点以及各技术在糖蛋白质组学研究中的应用和贡献。

English

    1. [1] Ohtsubo K, Marth J D. Cell, 2006, 126:855

    2. [2] Walsh G, Jefferis R. Nat Biotechnol, 2006, 24:1241

    3. [3] Peracaula R, Barrab S, Sarrats A, et al. Dis Markers, 2008, 25(4/5):207

    4. [4] Comunale M A, Lowman M, Long R E, et al. J Proteome Res, 2006, 5(2):308

    5. [5] Johnson P J. J Gastroen Hepatol, 1999, 14:S32

    6. [6] Drake R R, Schwegler E E, Malik G, et al. Mol Cell Proteomics, 2006, 5(10):1957

    7. [7] Zhang S Z. Glycobiology and Biological Engineering. Beijing:Tsinghua University Press, 2002:97 张树政. 糖生物学和糖生物工程. 北京:清华大学出版社, 2002:97

    8. [8] Haltiwanger R S, Lowe J B. Annu Rev Biochem, 2004, 73:491

    9. [9] Kolli V, Schumacher K N, Dodds E D. Bioanalysis, 2015, 7:113

    10. [10] Vosseller K, Trinidad J C, Chalkley R J, et al. Mol Cell Proteomics, 2006, 5:923

    11. [11] Qiu R, Regnier F E. Anal Chem, 2005, 77:2802

    12. [12] Comer F I, Vosseller K, Wells L, et al. Anal Biochem, 2001, 293:169

    13. [13] Ball L E, Berkaw M N, Buse M G. Mol Cell Proteomics, 2006, 5:313

    14. [14] Ding W, Hill J J, Kelly J. Anal Chem, 2007, 79:8891

    15. [15] Zhao J, Simeone D M, Heidt D, et al. J Proteome Res, 2006, 5:1792

    16. [16] Ongay S, Boichenko A, Govorukhina N, et al. J Sep Sci, 2012, 35:2341

    17. [17] Liu X C. Chinese Journal of Chromatography, 2006, 24(1):73 刘小川. 色谱, 2006, 24(1):73

    18. [18] Zhang L J, Xu Y W, Yao H L, et al. Chem-Eur J, 2009, 15:10158

    19. [19] Wang Y L, Liu M B, Xie L Q, et al. Anal Chem, 2014, 86:2057

    20. [20] Ma R N, Hu J J, Cai Z W, et al. Nanoscale, 2014, 6:3150

    21. [21] Chen Y J, Xiong Z C, Zhang L Y, et al. Nanoscale, 2015, 7:3100

    22. [22] Xu Y W, Wu Z X, Zhang L J, et al. Anal Chem, 2009, 81:503

    23. [23] Liu L T, Zhang Y, Zhang L, et al. Anal Chim Acta, 2012, 753:64

    24. [24] Wang H Y, Bie Z J, Lu C C, et al. Chem Sci, 2013, 4:4298

    25. [25] Zhang Y T, Ma W F, Li D, et al. Small, 2014, 10:1379

    26. [26] Li D J, Chen Y, Liu Z. Chem Soc Rev, 2015, 44:8097

    27. [27] Pan X H, Chen Y, Zhao P X, et al. Angew Chem Int Ed, 2015, 54:6173

    28. [28] Li H Y, Wang H Y, Liu Y C, et al. Chem Commun, 2012, 48:4115

    29. [29] Ye J, Chen Y, Liu Z. Angew Chem Int Ed, 2014, 53:10386

    30. [30] Cao J, Shen C P, Wang H, et al. J Proteome Res, 2009, 8:662

    31. [31] Zhang H, Li X J, Martin D B, et al. Nat Biotechnol, 2003, 21:660

    32. [32] Zou Z Q, Ibisate M, Zhou Y, et al. Anal Chem, 2008, 80:1228

    33. [33] Tran T H, Park S Y, Lee H, et al. Analyst, 2012, 137:991

    34. [34] Zhang L J, Jiang H C, Yao J, et al. Chem Commun, 2014, 50:1027

    35. [35] Liu L T, Yu M, Zhang Y, et al. ACS Appl Mater Interfaces, 2014, 6:7823

    36. [36] Sun B Y, Ranish J A, Utleg A G, et al. Mol Cell Proteomics, 2007, 6(1):141

    37. [37] Wollscheid B, Bausch-Fluck D, Henderson C, et al. Nat Biotechnol, 2009, 27(4):378

    38. [38] Nilsson J, Ruetschi U, Halim A, et al. Nat Methods, 2009, 6:809

    39. [39] Klement E, Lipinszki Z, Kupihar Z, et al. J Proteome Res, 2010, 9:2200

    40. [40] Abdel-Magid A F, Carson K G, Harris B D, et al. J Org Chem, 1996, 61:3849

    41. [41] Zhang Y, Kuang M, Zhang L J, et al. Anal Chem, 2013, 85:5535

    42. [42] Zhang Z, Sun D G, Cong Y T, et al. J Proteome Res, 2015, 14:3892

    43. [43] Kaneshiro K, Fukuyama Y, Iwamoto S, et al. Anal Chem, 2011, 83:3663

    44. [44] Snovida S I, Chen V C, Perreault H. Anal Chem, 2006, 78:8561

    45. [45] Zhang Y, Yu M, Zhang C, et al. Chem Commun, 2015, 51:5982

    46. [46] Pauloehrl T, Delaittre G, Bruns M, et al. Angew Chem Int Ed, 2012, 51:9181

    47. [47] Nishimura S I, Niikura K, Kurogochi M, et al. Angew Chem Int Ed, 2005, 44:91

    48. [48] Kurogochi M, Amano M, Fumoto M, et al. Angew Chem Int Ed, 2007, 46:8808

    49. [49] Zeng Y, Ramya T N C, Dirksen A, et al. Nat Methods, 2009, 6:207

    50. [50] Ramya T N C, Weerapana E, Cravatt B F, et al. Glycobiology, 2013, 23:211

    51. [51] Zhang Y, Yu M, Zhang C, et al. Anal Chem, 2014, 86:7920

    52. [52] Zhang W, Cao W Q, Huang J M, et al. Analyst, 2015, 140:1082

    53. [53] Zhang W, Wang H, Tang H L, et al. Anal Chem, 2011, 83:4975

    54. [54] Zhang W, Wang H, Zhang L, et al. Talanta, 2011, 85(1):499

    55. [55] Zhao Y, Jia W, Wang J F. Anal Chem, 2011, 83:8802

    56. [56] Jia W, Lu Z, Fu Y, et al. Mol Cell Proteomics, 2009, 8(5):913

    57. [57] Llop E, Gallego R G, Belalcazar V, et al. Proteomics, 2007, 7(23):4278

    58. [58] Harazono A, Kawasaki N, Itoh S, et al. Anal Biochem, 2006, 348(2):259

    59. [59] Wells L, Vosseller K, Cole R N, et al. Mol Cell Proteomics, 2002, 1:791

    60. [60] Zheng Y F, Guo Z H, Cai Z W. Talanta, 2009, 78:358

    61. [61] Ashline D J, Yu Y, Lasanajak Y, et al. Mol Cell Proteomics, 2014, 13:2961

    62. [62] Song X Z, Ju H, Lasanajak Y, et al. Nat Methods, 2016, 13(6):528

    63. [63] Hawkins C L, Davies M J. Biochem J, 1998, 332:617

    64. [64] Ohno N, Uchiyama M, Tsuzuki A, et al. Carbohydr Res, 1999, 316:161

    65. [65] Rees M D, Hawkins C L, Davies M J, et al. J Am Chem Soc, 2003, 125:13719

    66. [66] Rees M D, Davies M J. J Am Chem Soc, 2006, 128:3085

    67. [67] Sparbier K, Wenzel T, Kostrzewa M. J Chromatogr B, 2006, 840:29

    68. [68] Sun B Y, Ranish J A, Utleg A G, et al. Mol Cell Proteomics, 2007, 6:141

    69. [69] Tian Y, Zhou Y, Elliott S, et al. Nat Protoc, 2007, 2:334

    70. [70] Yang S, Li Y, Shah P, et al. Anal Chem, 2013, 85(11):5555

    71. [71] Shah P, Yang S, Sun S S, et al. Anal Chem, 2013, 85(7):3606

    72. [72] Yin B J, Gao Y, Chung C Y, et al. Biotechnol Bioeng, 2015, 112(11):2343

    73. [73] Lin N, Mascarenhas J, Sealover N R, et al. Biotechnol Prog, 2015, 31(2):334

    74. [74] Yang S, Wang M Y, Chen L J, et al. Scientific Reports, 2015, 5:17585

    75. [75] Yang S, Yuan W, Yang W M, et al. Anal Chem, 2013, 85(17):8188

    76. [76] Zhou Y, Aebersold R, Zhang H. Anal Chem, 2007, 79(15):5826

    77. [77] Zou Z Q, Ibisate M, Zhou Y, et al. Anal Chem, 2008, 80(4):1228

    78. [78] Sun S S, Shah P, Eshghi S T, et al. Nat Biotechol, 2016, 34:84

    79. [79] Yang S J, Zhang H. Anal Chem, 2012, 84(5):2232

    80. [80] Nilsson J, Ruetschi U, Halim A, et al. Nat Methods, 2009, 6:809

    81. [81] Klement E, Lipinszki Z, Kupihar Z, et al. J Proteome Res, 2010, 9:2200

    82. [82] Weng Y J, Sui Z G, Jiang H, et al. Scientific Reports, 2015, 5:9770

    83. [83] Jiang H, Yuan H M, Qu Y Y, et al. Talanta, 2016, 146:225

    84. [84] Wu C, Liang Yu, Zhao Q, et al. Chem-Eur J, 2014, 20(28):8737

    85. [85] Liang Y, Wu C, Zhao Q, et al. Anal Chim Acta, 2015, 900:83

    86. [86] Zielinska D F, Gnad F, Wisniewski J R, et al. Cell, 2010, 141:897

    87. [87] Zhu J, Sun Z, Cheng K, et al. J Proteome Res, 2014, 13:1713

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  • 收稿日期:  2016-09-01
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