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单克隆抗体药物糖基化修饰分析研究进展

丛宇婷 ,  胡良海

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引用本文: 丛宇婷,  胡良海. 单克隆抗体药物糖基化修饰分析研究进展[J]. 色谱, 2016, 34(12): 1186-1191. doi: 10.3724/SP.J.1123.2016.08035 shu
Citation:  CONG Yuting,  HU Lianghai. Recent advances on the analysis of glycosylation of therapeutic monoclonal antibodies[J]. Chinese Journal of Chromatography, 2016, 34(12): 1186-1191. doi: 10.3724/SP.J.1123.2016.08035 shu

单克隆抗体药物糖基化修饰分析研究进展

  • 吉林大学生命科学学院, 吉林 长春 130012

  • 基金项目:

    国家自然科学基金项目（81373374）.

摘要: 单克隆抗体药物是一类以免疫球蛋白G的结构为基础的大分子糖蛋白药物，为癌症、自身免疫疾病以及病毒感染等多种疾病的治疗提供了全新的途径。单抗药物的糖基化修饰类型及水平对其稳定性、清除率、免疫原性、抗体依赖细胞毒性及补体依赖细胞毒性等都有一定的影响。单抗药物的迅速发展及其在多种疾病治疗中日益凸显的重要性都对单抗药物的研发及用药安全等方面提出了更高的要求。因此，建立规范可靠的单抗药物糖基化修饰分析方法有着十分重要的意义。该综述将简要介绍单克隆抗体药物糖基化修饰及相关的定性、定量分析方法。

English

    1. [1] Kohler G, Milstein C. Nature, 1975, 256(5517):495

    2. [2] Liu J K. Ann Med Surg (Lond), 2014, 3(4):113

    3. [3] Hnasko R M, Stanker L H. Methods Mol Biol, 2015, 1318:15

    4. [4] Weiner L M, Surana R, Wang S. Nat Rev Immunol, 2010, 10(5):317

    5. [5] Chen Z, Wang J, Bao L, et al. Nat Commun, 2015, 6:6714

    6. [6] Oliphant T, Engle M, Nybakken G E, et al. Nat Med, 2005, 11(5):522

    7. [7] Isaacs J D. Arthritis Res Ther, 2009, 11(3):225

    8. [8] Bayry J, Lacroix-Desmazes S, Kazatchkine M D, et al. Nat Clin Pract Rheumatol, 2007, 3(5):262

    9. [9] Hogarth P M, Pietersz G A. Nat Rev Drug Discov, 2012, 11(4):311

    10. [10] Mauri C, Mars L T, Londei M. Nat Med, 2000, 6(6):673

    11. [11] Berman D, Korman A, Peck R, et al. Pharmacol Ther, 2015, 148:132

    12. [12] Weiner L M. J Immunother, 2006, 29(1):1

    13. [13] Reichert J M. MAbs, 2015, 7(1):1

    14. [14] Ecker D M, Jones S D, Levine H L. MAbs, 2015, 7(1):9

    15. [15] Reusch D, Haberger M, Maier B, et al. MAbs, 2015, 7(1):167

    16. [16] Sinha S, Pipes G, Topp E M, et al. J Am Soc Mass Spectrom, 2008, 19(11):1643

    17. [17] Janin-Bussat M C, Tonini L, Huillet C, et al. Methods Mol Biol, 2013, 988:93

    18. [18] Ha S, Wang Y, Rustandi R R. MAbs, 2011, 3(5):453

    19. [19] Tanaka M, Koga A, Kobe A, et al. Eur J Pharm Biopharm, 2013, 83(2):123

    20. [20] Beck A, Wagner-Rousset E, Bussat M C, et al. Curr Pharm Biotechnol, 2008, 9(6):482

    21. [21] Song T, Ozcan S, Becker A, et al. Anal Chem, 2014, 86(12):5661

    22. [22] Jefferis R. Arch Biochem Biophys, 2012, 526(2):159

    23. [23] Hokke C H, Bergwerff A A, Van Dedem G W, et al. FEBS Lett, 1990, 275(1/2):9

    24. [24] Hamilton S R, Gerngross T U. Curr Opin Biotechnol, 2007, 18(5):387

    25. [25] Sheeley D M, Merrill B M, Taylor L C. Anal Biochem, 1997, 247(1):102

    26. [26] Beck A, Klinguer-Hamour C, Bussat M C, et al. J Pept Sci, 2007, 13(9):588

    27. [27] Triguero A, Cabrera G, Royle L, et al. Anal Biochem, 2010, 400(2):173

    28. [28] Beck A, Wagner-Rousset E, Ayoub D, et al. Anal Chem, 2013, 85(2):715

    29. [29] Chung S, Quarmby V, Gao X, et al. MAbs, 2012, 4(3):326

    30. [30] Scallon B J, Tam S H, McCarthy S G, et al. Mol Immunol, 2007, 44(7):1524

    31. [31] Anonymous. Biotechnol Law Rep, 2012, 31:171

    32. [32] Said N, Gahoual R, Kuhn L, et al. Anal Chim Acta, 2016, 918:50

    33. [33] Reusch D, Haberger M, Falck D, et al. MAbs, 2015, 7(4):732

    34. [34] Geyer H, Geyer R. Biochim Biophys Acta, 2006, 1764(12):1853

    35. [35] Stadlmann J, Pabst M, Kolarich D, et al. Proteomics, 2008, 8(14):2858

    36. [36] Tran B Q, Barton C, Feng J, et al. J Proteomics, 2016, 134:93

    37. [37] Zhang Z, Pan H, Chen X. Mass Spectrom Rev, 2009, 28(1):147

    38. [38] Beck A, Debaene F, Diemer H, et al. J Mass Spectrom, 2015, 50(2):285

    39. [39] Xie H, Chakraborty A, Ahn J, et al. MAbs, 2010, 2(4):379

    40. [40] Ayoub D, Jabs W, Resemann A, et al. MAbs, 2013, 5(5):699

    41. [41] Xu C F, Zang L, Weiskopf A. J Chromatogr B, 2014, 960:230

    42. [42] Liu H, Gaza-Bulseco G, Chumsae C. J Am Soc Mass Spectrom, 2009, 20(12):2258

    43. [43] Makarov A. Anal Chem, 2000, 72(6):1156

    44. [44] Zhao S S, Chen D D. Electrophoresis, 2014, 35(1):96

    45. [45] Haselberg R, de Jong G J, Somsen G W. Anal Chem, 2013, 85(4):2289

    46. [46] Thakur D, Rejtar T, Karger B L, et al. Anal Chem, 2009, 81(21):8900

    47. [47] Reichel C, Thevis M. Bioanalysis, 2013, 5(5):587

    48. [48] De Kort B J, De Jong G J, Somsen G W. Electrophoresis, 2012, 33(19/20):2996

    49. [49] Schiestl M, Stangler T, Torella C, et al. Nat Biotechnol, 2011, 29(4):310

    50. [50] Federici M, Lubiniecki A, Manikwar P, et al. Biologicals, 2013, 41(3):131

    51. [51] Staub A, Guillarme D, Schappler J, et al. J Pharm Biomed Anal, 2011, 55(4):810

    52. [52] Merry A H, Neville D C, Royle L, et al. Anal Biochem, 2002, 304(1):91

    53. [53] Wada Y, Dell A, Haslam S M, et al. Mol Cell Proteomics, 2010, 9(4):719

    54. [54] Edge A S, Faltynek C R, Hof L, et al. Anal Biochem, 1981, 118(1):131

    55. [55] Sanchez-De Melo I, Grassi P, Ochoa F, et al. J Proteomics, 2015, 127:225

    56. [56] Marino K, Bones J, Kattla J J, et al. Nat Chem Biol, 2010, 6(10):713

    57. [57] Zhang L, Luo S, Zhang B. MAbs, 2016, 8(2):205

    58. [58] Pabst M, Altmann F. Proteomics, 2011, 11(4):631

    59. [59] Grey C, Edebrink P, Krook M, et al. J Chromatogr B, 2009, 877(20/21):1827

    60. [60] Harvey D J. J Am Soc Mass Spectrom, 2005, 16(5):647

    61. [61] Harvey D J. J Am Soc Mass Spectrom, 2005, 16(5):631

    62. [62] Harvey D J. J Am Soc Mass Spectrom, 2005, 16(5):622

    63. [63] Wormald M R, Petrescu A J, Pao Y L, et al. Chem Rev, 2002, 102(2):371

    64. [64] Halbeek H. Methods Mol Biol, 1993, 17:115

    65. [65] Chen Y H, Yan G Q, Zhou X W, et al. Chinese Journal of Chromatography, 2010, 28(2):135 陈瑶函, 晏国全, 周新文, 等. 色谱, 2010, 28(2):135

    66. [66] Cooper C A, Gasteiger E, Packer N H. Proteomics, 2001, 1(2):340

    67. [67] Go E P, Rebecchi K R, Dalpathado D S, et al. Anal Chem, 2007, 79(4):1708

    68. [68] Ozohanics O, Krenyacz J, Ludanyi K, et al. Rapid Commun Mass Spectrom, 2008, 22(20):3245

    69. [69] Cheng K, Chen R, Seebun D, et al. J Proteomics, 2014, 110:145

    70. [70] Toyama A, Nakagawa H, Matsuda K, et al. Anal Chem, 2012, 84(22):9655

    71. [71] Hong Q, Lebrilla C B, Miyamoto S, et al. Anal Chem, 2013, 85(18):8585

    72. [72] Yang N, Goonatilleke E, Park D, et al. Anal Chem, 2016, 88(14):7091

    73. [73] Zhang H, Li X J, Martin D B, et al. Nat Biotechnol, 2003, 21(6):660

    74. [74] Kaji H, Saito H, Yamauchi Y, et al. Nat Biotechnol, 2003, 21(6):667

    75. [75] Alpert A J. J Chromatogr, 1988, 444:269

    76. [76] O'Shannessy D J, Hoffman W L. Biotechnol Appl Biochem, 1987, 9(6):488

    77. [77] Alpert A J. J Chromatogr, 1990, 499:177

    78. [78] Ma C, Pan Y T, Zhang Q, et al. Chinese Journal of Chromatography, 2013, 31(11):1057 马成, 潘一廷, 张琪, 等. 色谱, 2013, 31(11):1057

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  • 收稿日期:  2016-08-29
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