Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes

Qing Fang CHENG Xing You XU Ming Yan WANG Jun CHEN Wei Xing MA Xu Jie YANG

引用本文: Qing Fang CHENG,  Xing You XU,  Ming Yan WANG,  Jun CHEN,  Wei Xing MA,  Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters, 2006, 17(7): 887-890. shu
Citation:  Qing Fang CHENG,  Xing You XU,  Ming Yan WANG,  Jun CHEN,  Wei Xing MA,  Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters, 2006, 17(7): 887-890. shu

Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes

摘要: Asymmetric pinacol coupling of aromatic aldehydes with TiCl4-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1, 2-diols in excellent yields with high dl-diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed.

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  • 收稿日期:  2006-01-10
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