引用本文:
Qing Fang CHENG, Xing You XU, Ming Yan WANG, Jun CHEN, Wei Xing MA, Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters,
2006, 17(7): 887-890.
Citation: Qing Fang CHENG, Xing You XU, Ming Yan WANG, Jun CHEN, Wei Xing MA, Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters, 2006, 17(7): 887-890.

Citation: Qing Fang CHENG, Xing You XU, Ming Yan WANG, Jun CHEN, Wei Xing MA, Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters, 2006, 17(7): 887-890.

Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes
摘要:
Asymmetric pinacol coupling of aromatic aldehydes with TiCl4-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1, 2-diols in excellent yields with high dl-diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed.
English
Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes
Abstract:
Asymmetric pinacol coupling of aromatic aldehydes with TiCl4-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1, 2-diols in excellent yields with high dl-diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed.
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Key words:
- Chiral squaric acid amidoalcohol
- / pinacol
- / asymmetric coupling
- / aromatic aldehyde

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