引用本文:
Qing Song ZHOU, Xue Hua JIANG, Jia Rui YU, Ke Jia LI. Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin[J]. Chinese Chemical Letters,
2006, 17(1): 85-88.
Citation: Qing Song ZHOU, Xue Hua JIANG, Jia Rui YU, Ke Jia LI. Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin[J]. Chinese Chemical Letters, 2006, 17(1): 85-88.
Citation: Qing Song ZHOU, Xue Hua JIANG, Jia Rui YU, Ke Jia LI. Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin[J]. Chinese Chemical Letters, 2006, 17(1): 85-88.
Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin
摘要:
Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol (PEG) were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scutellarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scutellarin.
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关键词:
- Scutellarin
- / PEGylation
- / prodrug
- / physicochemical properties
- / stability
English
Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin
Abstract:
Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol (PEG) were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scutellarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scutellarin.
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Key words:
- Scutellarin
- / PEGylation
- / prodrug
- / physicochemical properties
- / stability
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