Removal of Endotoxin from Human Serum Albumin Solutions by Hydrophobic and Cationic Charged Membrane

Gui Lin WEI Zhen Hua SHAN Ming Chen PAN Zhi Hong GAO

引用本文: Gui Lin WEI,  Zhen Hua SHAN,  Ming Chen PAN,  Zhi Hong GAO. Removal of Endotoxin from Human Serum Albumin Solutions by Hydrophobic and Cationic Charged Membrane[J]. Chinese Chemical Letters, 2000, 11(4): 357-360. shu
Citation:  Gui Lin WEI,  Zhen Hua SHAN,  Ming Chen PAN,  Zhi Hong GAO. Removal of Endotoxin from Human Serum Albumin Solutions by Hydrophobic and Cationic Charged Membrane[J]. Chinese Chemical Letters, 2000, 11(4): 357-360. shu

Removal of Endotoxin from Human Serum Albumin Solutions by Hydrophobic and Cationic Charged Membrane

  • 基金项目:

    This work was supported by the National Natural Science Foundation of China.

摘要: A novel matrix of macropore cellulose membrane was prepared by chemical graft, and immobilized the cationic charged groups as affinity ligands. The prepared membrane can be used for the removal of endotoxin from human serum albumin (HSA) solutions. With a cartridge of 20 sheets affinity membrane of 47 mm diameter, the endotoxin level in HSA solution can be reduced to 0.027 eu/mL. Recovery of HSA was over 95%.

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  • 收稿日期:  1999-07-22
  • 修回日期:  1999-12-28
通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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