引用本文:
Wei DENG, Ye Feng WANG, Lei LIU, Qing Xiang GUO. Synthesis of α-Arylated Esters from Aryl Halides[J]. Chinese Chemical Letters,
2006, 17(5): 595-598.
Citation: Wei DENG, Ye Feng WANG, Lei LIU, Qing Xiang GUO. Synthesis of α-Arylated Esters from Aryl Halides[J]. Chinese Chemical Letters, 2006, 17(5): 595-598.
Citation: Wei DENG, Ye Feng WANG, Lei LIU, Qing Xiang GUO. Synthesis of α-Arylated Esters from Aryl Halides[J]. Chinese Chemical Letters, 2006, 17(5): 595-598.
Synthesis of α-Arylated Esters from Aryl Halides
摘要:
An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α-arylalkanoic acids.
English
Synthesis of α-Arylated Esters from Aryl Halides
Abstract:
An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α-arylalkanoic acids.
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Key words:
- Cross coupling reaction
- / CuI
- / ethyl acetoacetate
- / aryl halide
- / α-arylalkanoic acids
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