引用本文:
Pei Hua Shang, Chang Mei Cheng, Hua Wang, Hong Chao Zheng, Yu Fen Zhao. Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine[J]. Chinese Chemical Letters,
2010, 21(2): 131-134.
doi:
10.1016/j.cclet.2009.10.017
Citation: Pei Hua Shang, Chang Mei Cheng, Hua Wang, Hong Chao Zheng, Yu Fen Zhao. Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine[J]. Chinese Chemical Letters, 2010, 21(2): 131-134. doi: 10.1016/j.cclet.2009.10.017
Citation: Pei Hua Shang, Chang Mei Cheng, Hua Wang, Hong Chao Zheng, Yu Fen Zhao. Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine[J]. Chinese Chemical Letters, 2010, 21(2): 131-134. doi: 10.1016/j.cclet.2009.10.017
Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine
摘要:
An efficient and novel method for synthesizing 3',5'-dithio-2'-deoxyguanosine was described.In this method normal guanosine was used as the starting material.A very efficient procedure was used to synthesize 2'-O-tosyiguanosine 1,which used 0.1 eq.DBTO instead of 2 eq.1 was treated with LTBH to give 9-(2-deoxy-β-D-threo-pentofuranosyl)guanine 2.2 could be easily turned to the target compound.
English
Study on disulfur-backboned nucleic acids:Part Ⅳ.Efficient synthesis of 3',5'-dithio-2'-deoxyguanosine
Abstract:
An efficient and novel method for synthesizing 3',5'-dithio-2'-deoxyguanosine was described.In this method normal guanosine was used as the starting material.A very efficient procedure was used to synthesize 2'-O-tosyiguanosine 1,which used 0.1 eq.DBTO instead of 2 eq.1 was treated with LTBH to give 9-(2-deoxy-β-D-threo-pentofuranosyl)guanine 2.2 could be easily turned to the target compound.
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Key words:
- 3',5'-Dithio-2'-deoxyguanosine
- / Guanosine
- / Synthesis
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