引用本文:
Hong Xia DING, Wei LU, Lei Xiang YANG, Hai Bo LI, Hua BAI, Xiu Mei WU, Jun Chao CAI, Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters,
2006, 17(1): 5-8.
Citation: Hong Xia DING, Wei LU, Lei Xiang YANG, Hai Bo LI, Hua BAI, Xiu Mei WU, Jun Chao CAI, Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters, 2006, 17(1): 5-8.
Citation: Hong Xia DING, Wei LU, Lei Xiang YANG, Hai Bo LI, Hua BAI, Xiu Mei WU, Jun Chao CAI, Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters, 2006, 17(1): 5-8.
Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue
摘要:
Artabotrine 1 is a novel N-methoxylated 4, 5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.
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关键词:
- Artabotrine
- / aporphine alkaloid
- / cytotoxicity
- / synthesis
English
Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue
Abstract:
Artabotrine 1 is a novel N-methoxylated 4, 5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.
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Key words:
- Artabotrine
- / aporphine alkaloid
- / cytotoxicity
- / synthesis
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