引用本文:
Guo Qiang HU, Sheng LI, Wen Long HUANG, Hai WANG. Synthesis and Bioactivity of Arecoline Derivatives Containing Amino-s-triazole Coupled Oxadiazole[J]. Chinese Chemical Letters,
2006, 17(1): 19-22.
Citation: Guo Qiang HU, Sheng LI, Wen Long HUANG, Hai WANG. Synthesis and Bioactivity of Arecoline Derivatives Containing Amino-s-triazole Coupled Oxadiazole[J]. Chinese Chemical Letters, 2006, 17(1): 19-22.
Citation: Guo Qiang HU, Sheng LI, Wen Long HUANG, Hai WANG. Synthesis and Bioactivity of Arecoline Derivatives Containing Amino-s-triazole Coupled Oxadiazole[J]. Chinese Chemical Letters, 2006, 17(1): 19-22.
Synthesis and Bioactivity of Arecoline Derivatives Containing Amino-s-triazole Coupled Oxadiazole
摘要:
5-(5"-Substituted phenyl-[1", 3", 4"]oxadiazol-2"-yl methylsulfanyl)-3-pyridin-3'-yl-[1,2,4] triazol-4-yl amines 1a-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a-j. The reduction of compounds 2 with NaBH4 in methanol gave the target compounds 5-(5"-substituted phenyl-[1", 3", 4"]oxadiazol-2"-yl methylsulfanyl)-3-(1'-methyl-1', 2', 5', 6'-tetrahydropyridin-3'-yl)-[1,2,4]triazol-4-ylamines 3a-j. The endothelium vascular relaxing activity of the target compounds were screened.
English
Synthesis and Bioactivity of Arecoline Derivatives Containing Amino-s-triazole Coupled Oxadiazole
Abstract:
5-(5"-Substituted phenyl-[1", 3", 4"]oxadiazol-2"-yl methylsulfanyl)-3-pyridin-3'-yl-[1,2,4] triazol-4-yl amines 1a-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a-j. The reduction of compounds 2 with NaBH4 in methanol gave the target compounds 5-(5"-substituted phenyl-[1", 3", 4"]oxadiazol-2"-yl methylsulfanyl)-3-(1'-methyl-1', 2', 5', 6'-tetrahydropyridin-3'-yl)-[1,2,4]triazol-4-ylamines 3a-j. The endothelium vascular relaxing activity of the target compounds were screened.
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Key words:
- Tetrahydropyridine
- / triazolylamine
- / oxadiazole
- / muscarinic agonist
- / vascular activity
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