Interaction between <i>N</i>-phosphoryl-α-, β- and γ-amino acids and nucleosides

引用本文: Li Ming Qiang, Shu Xia Cao, Yan Chun Guo, Xin Cheng Liao, Yu Fen Zhao. Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides[J]. Chinese Chemical Letters, 2007, 18(8): 939-942. doi: 10.1016/j.cclet.2007.05.032 shu

Citation: Li Ming Qiang, Shu Xia Cao, Yan Chun Guo, Xin Cheng Liao, Yu Fen Zhao. Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides[J]. Chinese Chemical Letters, 2007, 18(8): 939-942. doi: 10.1016/j.cclet.2007.05.032 shu

Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

a Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;
b Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China
基金项目:
The authors would like to thank the National Natural Science Foundation of China (Nos. 20572061, 20672104), the Chinese Ministry of Education and Zhengzhou University for financial support.

摘要: The reactions of four different N-(O, O'-diisopropyl) phosphoamino acids (DIPP-aa), such as N-phosphoryl-L-α-alanine (DIPPL-α-Ala), N-phosphoryl-D-α-alanine (DIPP-D-α-Ala), N-phosphoryl-β-alanine (DIPP-β-Ala) and N-phosphoryl-γ-amino butyric acid (DIPP-γ-Aba), and four nucleosides, adenosine (A), guanosine (G), cytdine (C) and uridine (U), were studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and HPLC/ESI-MS. DIPP-L-α-Ala and D1PP-D-α-Ala produced the same phosphorylated nucleosides, dinucleotides and phosphoroligopeptide. However, DIPP-β-Ala and DIPP-γ-Aba gave no relevant products.

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Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

a Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;
b Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China
Received Date: 24 January 2007
Fund Project:
The authors would like to thank the National Natural Science Foundation of China (Nos. 20572061, 20672104), the Chinese Ministry of Education and Zhengzhou University for financial support.

Abstract: The reactions of four different N-(O, O'-diisopropyl) phosphoamino acids (DIPP-aa), such as N-phosphoryl-L-α-alanine (DIPPL-α-Ala), N-phosphoryl-D-α-alanine (DIPP-D-α-Ala), N-phosphoryl-β-alanine (DIPP-β-Ala) and N-phosphoryl-γ-amino butyric acid (DIPP-γ-Aba), and four nucleosides, adenosine (A), guanosine (G), cytdine (C) and uridine (U), were studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and HPLC/ESI-MS. DIPP-L-α-Ala and D1PP-D-α-Ala produced the same phosphorylated nucleosides, dinucleotides and phosphoroligopeptide. However, DIPP-β-Ala and DIPP-γ-Aba gave no relevant products.

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Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

English

Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

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Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

English

Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides

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