引用本文:
冀亚飞, 张雁秋, 石俊英. 维生素K1合成的改进[J]. 应用化学,
1998, 15(4): 98-100.
Citation: Ji Yafei, Zhang Yanqiu, Shi Junying. Improvement in Vitamin K1 Synthesis[J]. Chinese Journal of Applied Chemistry, 1998, 15(4): 98-100.
Citation: Ji Yafei, Zhang Yanqiu, Shi Junying. Improvement in Vitamin K1 Synthesis[J]. Chinese Journal of Applied Chemistry, 1998, 15(4): 98-100.
English
Improvement in Vitamin K1 Synthesis
Abstract:
The Ruettimnann's method[5] for vitamin K1 synthesis has been improved by using phase transfer catalyst in Diels-Alder condensation and using mixed trans-cis phytyl chloride instead of natural phytol as starting material in the synthesis. The vitamin K1 then obtained by a retro-Diels-Alder reaction has a cis-trans isomer ratio of 20.35 to 79.65 which meets the Chinese pharmacopia standard. Phytyl bromide in this case gave vitamin K1 with cis-trans ratio of 26.30 to 73.70.
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Key words:
- vitamin K1
- / synthesis
- / phytyl chloride
- / phytyl bromide
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