基于行波技术的离子迁移率分离器研制

引用本文: 郭星, 赵忠俊, 代渐雄, 贺飞耀, 李宏, 王佳宇, 刘薇, 王昕, 张歆雪, 杨燕婷, 段忆翔. 基于行波技术的离子迁移率分离器研制[J]. 分析化学, 2021, 49(9): 1461-1469. doi: 10.19756/j.issn.0253-3820.210458 shu

Citation: GUO Xing, ZHAO Zhong-Jun, DAI Jian-Xiong, HE Fei-Yao, LI Hong, WANG Jia-Yu, LIU Wei, WANG Xin, ZHANG Xin-Xue, YANG Yan-Ting, DUAN Yi-Xiang. Development of A Travelling Wave-based Ion Mobility Spectrometer[J]. Chinese Journal of Analytical Chemistry, 2021, 49(9): 1461-1469. doi: 10.19756/j.issn.0253-3820.210458 shu

基于行波技术的离子迁移率分离器研制

郭星 ^1, ,
赵忠俊 ^2, ,
代渐雄 ^1, ,
贺飞耀 ^3, ,
李宏 ^3, ,
王佳宇 ^1, ,
刘薇 ^4, ,
王昕 ^1, ,
张歆雪 ^1, ,
杨燕婷 ^5, ,
段忆翔 ^{1,5,
,}

1.
西北大学化学与材料科学学院, 西安 710127;
2.
四川大学化学工程学院, 成都 610064;
3.
四川大学生命科学学院, 成都 610064;
4.
西北大学信息科学与技术学院, 西安 710127;
5.
成都艾立本科技有限公司, 成都 611930

通讯作者: 段忆翔,E-mail:yduan@scu.edu.cn

基金项目:
四川省重大科学仪器设备专项（No.2019ZDZX0036）和陕西省重点研究开发计划项目（No.2019ZDLSF01-03）资助。

摘要: 离子迁移谱（Ion mobility spectrometer，IMS）是一种重要的分子碰撞截面分析技术，漂移管是IMS中对样品离子有效分离的核心部件。本工作研制并表征了一种基于行波技术的离子迁移率分离器（Traveling wave ion mobility spectrometer，TWIMS），详细研究并讨论了行波电压幅值、行波移动速度、离子门脉冲宽度以及工作气压对仪器性能的影响。基于理论模拟对上述参数进行实验优化，当行波场电压幅值为50 V、行波场移动速度为162.5 m/s、离子门脉冲宽度为13 ms、工作气压为170 Pa时，此设备能以一种经济简便的方式获得与当前市售行波离子迁移-飞行时间质谱（Traveling wave ion mobilityspectrometer-Time of flight mass spectrometer，TWIMS-TOFMS）联用仪相媲美的迁移率分辨能力。此仪器对利血平的检出限为2.5 ng/mL，线性响应范围高于2个数量级（R²>0.999），性能优于传统IMS谱仪。TWIMS不仅可作为高性能IMS设备独立使用，而且有望与飞行时间质谱仪联用。

关键词:

English

Development of A Travelling Wave-based Ion Mobility Spectrometer

1.
College of Chemistry & Materials Science, Northwest University, Xi'an 710127, China;
2.
School of Chemical Engineering, Sichuan University, Chengdu 610064, China;
3.
College of Life Sciences, Sichuan University, Chengdu 610064, China;
4.
College of Information Science & Technology, Northwest University, Xi'an 710127, China;
5.
Aliben Science & Technology Co., Ltd, Chengdu 611930, China

Corresponding author: DUAN Yi-Xiang, yduan@scu.edu.cn

Received Date: 23 April 2021
Revised Date: 21 June 2021
Fund Project:
Supported by the Special Project of Major Scientific Instruments and Equipment in Sichuan Province, China (No.2019ZDZX0036) and the Key Research and Development Program of Shaanxi Province, China (No.2019ZDLSF01-03).

Abstract: Ion mobility spectrometry (IMS) is a rapid separation technique that has been successfully used for detection of chemical warfare agents, drugs and explosives. The key component of IMS is the drift tube, which plays an important role in effectively separating substances. Traditionally, the drift tube is a fixed-length separation space in which the influence of a uniformly applied weak electric field. In this work, the performance of traveling wave ion mobility spectrometer (TWIMS) was characterized by traveling wave voltage amplitudes, traveling wave speeds, ion gate pulse widths and working pressures. When the traveling wave field voltage amplitude was 50 V, the traveling wave field moving speed was 162.5 m/s, the ion gate pulse width was 13 ms, and the working pressure was 170 Pa, the device demonstrated highly analytical performance and achieved an ion mobility resolution comparable to a commercial traveling wave ion mobility time-of-flight mass spectrometry (TWIMS-MS). Finally, reserpine was used to test the linear response range of the TWIMS. The results showed that the linear response range of the TWIMS was greater than two orders of magnitude and the limit of detection could reach 2.5 ng/mL. The device was expected to be used in conjunction with a time-of-flight mass spectrometer.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于行波技术的离子迁移率分离器研制

通讯作者: 段忆翔,E-mail:yduan@scu.edu.cn

English

Development of A Travelling Wave-based Ion Mobility Spectrometer

Corresponding author: DUAN Yi-Xiang, yduan@scu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于行波技术的离子迁移率分离器研制

通讯作者: 段忆翔,E-mail:yduan@scu.edu.cn

English

Development of A Travelling Wave-based Ion Mobility Spectrometer

Corresponding author: DUAN Yi-Xiang, yduan@scu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

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