引用本文:
Li Ming Zhao, Tian Pei Xie, Yu Qin He, De Feng Xu, Shao Shun Li. Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones[J]. Chinese Chemical Letters,
2008, 19(10): 1206-1208.
doi:
10.1016/j.cclet.2008.06.046
Citation: Li Ming Zhao, Tian Pei Xie, Yu Qin He, De Feng Xu, Shao Shun Li. Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones[J]. Chinese Chemical Letters, 2008, 19(10): 1206-1208. doi: 10.1016/j.cclet.2008.06.046
Citation: Li Ming Zhao, Tian Pei Xie, Yu Qin He, De Feng Xu, Shao Shun Li. Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones[J]. Chinese Chemical Letters, 2008, 19(10): 1206-1208. doi: 10.1016/j.cclet.2008.06.046
Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones
摘要:
Sixteen novel 6-and 2-(1-aeylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their eytotoxicifies were evaluated in vitro against BEL-7402,HT-29 and SPC-Al cell lines.The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line.Compound 16b exhibited the most potent antitumor activity among the tested compounds.
English
Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones
Abstract:
Sixteen novel 6-and 2-(1-aeylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their eytotoxicifies were evaluated in vitro against BEL-7402,HT-29 and SPC-Al cell lines.The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line.Compound 16b exhibited the most potent antitumor activity among the tested compounds.
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