Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H2O2 System

Min ZHU Xue Mei HUANG Han Xi SHEN

引用本文: Min ZHU,  Xue Mei HUANG,  Han Xi SHEN. Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H2O2 System[J]. Chinese Chemical Letters, 1997, 8(11): 979-982. shu
Citation:  Min ZHU,  Xue Mei HUANG,  Han Xi SHEN. Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H2O2 System[J]. Chinese Chemical Letters, 1997, 8(11): 979-982. shu

Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H2O2 System

  • 基金项目:

    Authors would be grateful to the National Natural Science Foundation of China for the financial support.

摘要: Eriochrome black T and Nitrosulfophenol S were advocated as the chemical models of carcinogenic non-aminoazo compounds.The main products of their oxidative cleavage in horseradish peroxidase/H2O2 system was identified as the benezenediazonium ion,the ultimate carcinogens,which could bind to DNA.The reaction conditions were investigated preliminarily.Some inhibitors and inducers of the reaction were discovered.

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  • 收稿日期:  1997-06-23
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