引用本文:
Di Zao Li, Xian Dao Pan, Hong Yan Liu, Song Wu. Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins[J]. Chinese Chemical Letters,
2008, 19(10): 1202-1205.
doi:
10.1016/j.cclet.2008.07.022
Citation: Di Zao Li, Xian Dao Pan, Hong Yan Liu, Song Wu. Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins[J]. Chinese Chemical Letters, 2008, 19(10): 1202-1205. doi: 10.1016/j.cclet.2008.07.022
Citation: Di Zao Li, Xian Dao Pan, Hong Yan Liu, Song Wu. Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins[J]. Chinese Chemical Letters, 2008, 19(10): 1202-1205. doi: 10.1016/j.cclet.2008.07.022
Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins
摘要:
A series of 5-C-alkylating camptothecins have been synthesized by one-step method.and their in vitro antitumor activity was evaluated against six human cancer cell lines.The results showed that all 5-C-alkylatcs of camptothecins possessed poor cytotoxicity on six human cancer cell lines.
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关键词:
- Camptothecin
- / Synthesis
- / 5-C-Alkylate
- / Antitumor aetivity
English
Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins
Abstract:
A series of 5-C-alkylating camptothecins have been synthesized by one-step method.and their in vitro antitumor activity was evaluated against six human cancer cell lines.The results showed that all 5-C-alkylatcs of camptothecins possessed poor cytotoxicity on six human cancer cell lines.
-
Key words:
- Camptothecin
- / Synthesis
- / 5-C-Alkylate
- / Antitumor aetivity
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