Synthesis and Biological Evaluation of Novel 1, 5-Diarylpyrazole-3-carboxamide Compounds as Inhibitors of ALK5

Xian Ping DAI Xing Zhou LI Zhi Bing ZHENG Song LI

引用本文: Xian Ping DAI,  Xing Zhou LI,  Zhi Bing ZHENG,  Song LI. Synthesis and Biological Evaluation of Novel 1, 5-Diarylpyrazole-3-carboxamide Compounds as Inhibitors of ALK5[J]. Chinese Chemical Letters, 2006, 17(5): 609-612. shu
Citation:  Xian Ping DAI,  Xing Zhou LI,  Zhi Bing ZHENG,  Song LI. Synthesis and Biological Evaluation of Novel 1, 5-Diarylpyrazole-3-carboxamide Compounds as Inhibitors of ALK5[J]. Chinese Chemical Letters, 2006, 17(5): 609-612. shu

Synthesis and Biological Evaluation of Novel 1, 5-Diarylpyrazole-3-carboxamide Compounds as Inhibitors of ALK5

  • 基金项目:

    This work was supported by the Chinese National Basic Developing Project (973 project: 2004CB518908).

摘要: Ten new 1, 5-diarylpyrazole-3-carboxamide compounds were synthesized and their structures were identified by 1H-NMR and FAB-MS. The primary biological tests showed that compound 4j exhibited some ALK5 inhibitory activity at concentration of 1μmol/L.

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  • 收稿日期:  2005-11-23
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