引用本文:
Yan Chen, Rong Ning Liang, Wei Qin. Potentiometric sensor for sensitive and selective detection of heparin[J]. Chinese Chemical Letters,
2012, 23(2): 233-236.
doi:
10.1016/j.cclet.2011.10.021
Citation: Yan Chen, Rong Ning Liang, Wei Qin. Potentiometric sensor for sensitive and selective detection of heparin[J]. Chinese Chemical Letters, 2012, 23(2): 233-236. doi: 10.1016/j.cclet.2011.10.021

Citation: Yan Chen, Rong Ning Liang, Wei Qin. Potentiometric sensor for sensitive and selective detection of heparin[J]. Chinese Chemical Letters, 2012, 23(2): 233-236. doi: 10.1016/j.cclet.2011.10.021

Potentiometric sensor for sensitive and selective detection of heparin
摘要:
A polymeric membrane ion-selective electrode for determination of heparin is described in this paper. Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin. The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate. The potentiometric response to the concentration of heparin is linear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL is achieved.
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关键词:
- Potentiometry
- / Sensing element
- / Heparin
- / Protamine
- / Polyion sensor
English
Potentiometric sensor for sensitive and selective detection of heparin
Abstract:
A polymeric membrane ion-selective electrode for determination of heparin is described in this paper. Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin. The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate. The potentiometric response to the concentration of heparin is linear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL is achieved.
-
Key words:
- Potentiometry
- / Sensing element
- / Heparin
- / Protamine
- / Polyion sensor

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