Potentiometric sensor for sensitive and selective detection of heparin

Yan Chen Rong Ning Liang Wei Qin

引用本文: Yan Chen,  Rong Ning Liang,  Wei Qin. Potentiometric sensor for sensitive and selective detection of heparin[J]. Chinese Chemical Letters, 2012, 23(2): 233-236. doi: 10.1016/j.cclet.2011.10.021 shu
Citation:  Yan Chen,  Rong Ning Liang,  Wei Qin. Potentiometric sensor for sensitive and selective detection of heparin[J]. Chinese Chemical Letters, 2012, 23(2): 233-236. doi: 10.1016/j.cclet.2011.10.021 shu

Potentiometric sensor for sensitive and selective detection of heparin

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (No. 41176081), the Outstanding Youth Natural Science Foundation of Shandong Province (No. JQ200814), and the Taishan Scholar Program of Shandong Province (No. TS20081159).

摘要: A polymeric membrane ion-selective electrode for determination of heparin is described in this paper. Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin. The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate. The potentiometric response to the concentration of heparin is linear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL is achieved.

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  • 收稿日期:  2011-08-25
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