引用本文:
Qing Xiang Xiang, Li Qun Zhang, Xiao Qi Yu, Ru Gang Xie. Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes[J]. Chinese Chemical Letters,
2009, 20(5): 523-526.
doi:
10.1016/j.cclet.2009.01.001
Citation: Qing Xiang Xiang, Li Qun Zhang, Xiao Qi Yu, Ru Gang Xie. Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes[J]. Chinese Chemical Letters, 2009, 20(5): 523-526. doi: 10.1016/j.cclet.2009.01.001
Citation: Qing Xiang Xiang, Li Qun Zhang, Xiao Qi Yu, Ru Gang Xie. Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes[J]. Chinese Chemical Letters, 2009, 20(5): 523-526. doi: 10.1016/j.cclet.2009.01.001
Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes
摘要:
The activities of the catalytic hydrolysis of phosphate diester (BNPP)[bis (p-nitrophenyl)phosphate diester] and plasmid DNA (pUC18) by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with 1e-Zn(II) complex (composed of lipophilic group) as catalyst. The hydrolysis rate enhancement is up to 3.64×104 fold. These metal complexes could effectively promote the cleavage of plasmid DNA (pUC18) at physiological conditions.
English
Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes
Abstract:
The activities of the catalytic hydrolysis of phosphate diester (BNPP)[bis (p-nitrophenyl)phosphate diester] and plasmid DNA (pUC18) by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper. The results showed that the highest activity in hydrolysis of BNPP was obtained with 1e-Zn(II) complex (composed of lipophilic group) as catalyst. The hydrolysis rate enhancement is up to 3.64×104 fold. These metal complexes could effectively promote the cleavage of plasmid DNA (pUC18) at physiological conditions.
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Key words:
- Catalytic hydrolysis
- / Macrocyclic polyamine
- / Zn(II)complex
- / BNPP
- / Plasmid DNA
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