引用本文:
Jin Ming Zhang, Xiao Jun Zhang, Zhi Hong Xu, Jia He Tian. Radiosynthesis of N-11C-meisoindigotin as a novel PET agent for imaging of cyclin-dependent kinases and GSK-3β[J]. Chinese Chemical Letters,
2012, 23(2): 205-207.
doi:
10.1016/j.cclet.2011.10.014
Citation: Jin Ming Zhang, Xiao Jun Zhang, Zhi Hong Xu, Jia He Tian. Radiosynthesis of N-11C-meisoindigotin as a novel PET agent for imaging of cyclin-dependent kinases and GSK-3β[J]. Chinese Chemical Letters, 2012, 23(2): 205-207. doi: 10.1016/j.cclet.2011.10.014
Citation: Jin Ming Zhang, Xiao Jun Zhang, Zhi Hong Xu, Jia He Tian. Radiosynthesis of N-11C-meisoindigotin as a novel PET agent for imaging of cyclin-dependent kinases and GSK-3β[J]. Chinese Chemical Letters, 2012, 23(2): 205-207. doi: 10.1016/j.cclet.2011.10.014
Radiosynthesis of N-11C-meisoindigotin as a novel PET agent for imaging of cyclin-dependent kinases and GSK-3β
摘要:
Meisoindigotin has been demonstrated as a new type of cancer chemotherapeutic agent. N-11C-Meisoindigotin was synthesized by N-11C-methylation of the isoindigotin precursor with 11C-labelled methyl triflate. The decay corrected radiochemical yields were 15-25%,and the specific radioactivity was 1.0-1.2 Ci/μmol at the end of synthesis. The cellular uptake of[N-11C]meisoindigotin was evaluated in four different lung cancer cell lines. Our results showed that the A549, GLC-82, 95D cell lines exhibited higher uptake than 95C cell line after incubation for 60 min. N-11C-Meisoindigotin was a promising candidate for further development as a novel PET radiotracer for imaging of cyclin-dependent kinases (CDKs) and GSK-3β.
English
Radiosynthesis of N-11C-meisoindigotin as a novel PET agent for imaging of cyclin-dependent kinases and GSK-3β
Abstract:
Meisoindigotin has been demonstrated as a new type of cancer chemotherapeutic agent. N-11C-Meisoindigotin was synthesized by N-11C-methylation of the isoindigotin precursor with 11C-labelled methyl triflate. The decay corrected radiochemical yields were 15-25%,and the specific radioactivity was 1.0-1.2 Ci/μmol at the end of synthesis. The cellular uptake of[N-11C]meisoindigotin was evaluated in four different lung cancer cell lines. Our results showed that the A549, GLC-82, 95D cell lines exhibited higher uptake than 95C cell line after incubation for 60 min. N-11C-Meisoindigotin was a promising candidate for further development as a novel PET radiotracer for imaging of cyclin-dependent kinases (CDKs) and GSK-3β.
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Key words:
- N-Methylisoindigotin
- / Tumor imaging agent
- / Cyclin-dependent kinases
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