引用本文:
Ming Sheng Feng, Ping Guo, Li Xun Jiang, Jing Bo Shi, Yu Ping Cao, Qi Zheng Yao. Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase[J]. Chinese Chemical Letters,
2009, 20(2): 178-180.
doi:
10.1016/j.cclet.2008.10.027
Citation: Ming Sheng Feng, Ping Guo, Li Xun Jiang, Jing Bo Shi, Yu Ping Cao, Qi Zheng Yao. Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase[J]. Chinese Chemical Letters, 2009, 20(2): 178-180. doi: 10.1016/j.cclet.2008.10.027
Citation: Ming Sheng Feng, Ping Guo, Li Xun Jiang, Jing Bo Shi, Yu Ping Cao, Qi Zheng Yao. Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase[J]. Chinese Chemical Letters, 2009, 20(2): 178-180. doi: 10.1016/j.cclet.2008.10.027
Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase
摘要:
Seventeen 4-alkylamino/arylamino-substituted methotrexate (MTX) derivatives 6a-14a were designed and synthesized. Their inhibition activities against inducible nitric oxide synthase (iNOS) were evaluated in vitro. The pharmacological results showed that most of the prepared compounds displayed the potent inhibitory effects on iNOS.
English
Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase
Abstract:
Seventeen 4-alkylamino/arylamino-substituted methotrexate (MTX) derivatives 6a-14a were designed and synthesized. Their inhibition activities against inducible nitric oxide synthase (iNOS) were evaluated in vitro. The pharmacological results showed that most of the prepared compounds displayed the potent inhibitory effects on iNOS.
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Key words:
- Tetrahydrobiopterin
- / Inhibitor of nitric oxide synthase
- / Synthesis
- / Methotrexate
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