<i>β</i>-淀粉样蛋白的分析检测方法研究进展

引用本文: 蒋萌, 王晓英, 王小兵. β-淀粉样蛋白的分析检测方法研究进展[J]. 分析化学, 2018, 46(9): 1339-1349. doi: 10.11895/j.issn.0253-3820.171119 shu

Citation: JIANG Meng, WANG Xiao-Ying, WANG Xiao-Bing. Advances in Detection Methods of β-Amyloid Protein[J]. Chinese Journal of Analytical Chemistry, 2018, 46(9): 1339-1349. doi: 10.11895/j.issn.0253-3820.171119 shu

β-淀粉样蛋白的分析检测方法研究进展

1.
环境医学工程教育部重点实验室, 东南大学公共卫生学院, 南京 210009;
2.
天然药化教研室, 中国药科大学中药学院, 南京 210009
基金项目:
本文系国家自然科学基金项目（Nos.81573313，81302472）和江苏省高校"青蓝工程"资助

摘要: 阿尔兹海默症（AD）是一种神经退行性疾病，发病机制目前尚不明确。β-淀粉样蛋白（Aβ）是AD的特异性生物标志物之一，众多临床研究提示血液、脑脊液和脑组织内的Aβ水平异常与AD的病程进展密切相关。Aβ的分析评估对AD早期发现、跟踪、预防和治疗具有重要意义。本文就目前国内外Aβ的常用检测方法进行了概述和比较，重点阐述新型电化学生物传感方法在检测Aβ方面的相关应用及其最新研究进展，并对Aβ电化学传感技术的未来发展提出展望。

关键词:

English

Advances in Detection Methods of β-Amyloid Protein

1.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;
2.
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
Received Date: 21 July 2017
Revised Date: 05 June 2018
Fund Project:
This work was supported by the National Natural Science Foundation of China(Nos. 81573313, 81302472) and the "Blue Project" Funded by Universities in Jiangsu Province of China.

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology. Beta-amyloid protein (Aβ) is one of the specific biomarkers of AD, and many clinical studies suggest that abnormal levels of Aβ in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD. The analysis and evaluation of Aβ is important for early detection, tracking, prevention and treatment of AD. In this paper, the present situation of the commonly used detection methods of Aβ at home and abroad was summarized and compared. Specifically, the latest application of new electrochemical biosensor in Aβ detection was mainly described, and the summary of its future directions and the potential applications was given. It is intended to provide reference for the further research and application of Aβ.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

β-淀粉样蛋白的分析检测方法研究进展

English

Advances in Detection Methods of β-Amyloid Protein

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

β-淀粉样蛋白的分析检测方法研究进展

English

Advances in Detection Methods of β-Amyloid Protein

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

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