引用本文:
Xin Yong LIU, Wen Fang XU, Jing De WU. Synthesis of 4-Amino-5-furyl-2-yl-4H-1,2,4-triazole-3-thiol Derivatives as a Novel Class of Endothelin (ET) Receptor Antagonists[J]. Chinese Chemical Letters,
2003, 14(8): 790-793.
Citation: Xin Yong LIU, Wen Fang XU, Jing De WU. Synthesis of 4-Amino-5-furyl-2-yl-4H-1,2,4-triazole-3-thiol Derivatives as a Novel Class of Endothelin (ET) Receptor Antagonists[J]. Chinese Chemical Letters, 2003, 14(8): 790-793.
Citation: Xin Yong LIU, Wen Fang XU, Jing De WU. Synthesis of 4-Amino-5-furyl-2-yl-4H-1,2,4-triazole-3-thiol Derivatives as a Novel Class of Endothelin (ET) Receptor Antagonists[J]. Chinese Chemical Letters, 2003, 14(8): 790-793.
Synthesis of 4-Amino-5-furyl-2-yl-4H-1,2,4-triazole-3-thiol Derivatives as a Novel Class of Endothelin (ET) Receptor Antagonists
摘要:
A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1,2,4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor competitive binding assay showed that some compounds exhibited high selective as potent ET-1 receptor antagonist.
English
Synthesis of 4-Amino-5-furyl-2-yl-4H-1,2,4-triazole-3-thiol Derivatives as a Novel Class of Endothelin (ET) Receptor Antagonists
Abstract:
A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1,2,4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor competitive binding assay showed that some compounds exhibited high selective as potent ET-1 receptor antagonist.
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Key words:
- 1,2,4-Triazole derivatives
- / ET antagonist
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